Publications by authors named "Francisco Martins Teixeira"
Water is the main resource for maintaining life. Anthropic activities influence the microbial epidemiological chain in watersheds, which can act as ways of disseminating microorganisms resistant to antimicrobial drugs, with impacts on human, animal, and environmental health. Here, we characterized aquatic microbial communities and their resistomes in samples collected along Rio das Ostras watershed during two seasons.
View Article and Find Full Text PDFThe development of a nanoparticulate system for the carrier antigen is now an important tool in the vaccination process, since a smaller number of doses is necessary for effective immunization. Thus, in this work a nanoparticulate system using polymers of chitosan and poly (methacrylic acid) (CS-PMAA) to adsorb the Vi antigen of Typhi was developed. CS-PMAA nanoparticles with different proportions of chitosan and poly (methacrylic acid) were obtained and reached sizes from 123.
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- Chitosan is gaining attention for its unique properties that enhance drug delivery, particularly in combating typhoid fever using Vi Antigen nanoparticles.
- This study involved obtaining and characterizing Vi Antigen through Infrared spectroscopy and Computational Chemistry, revealing key structural insights and interactions.
- Two interaction models were proposed for Chitosan and Vi Antigen, showing how they bind at a molecular level, highlighting crucial interactions between acetyl groups and various functional groups in Chitosan.
Pyrostegia venusta (Ker Gawl.) Miers Crude Extract and Fractions: Prevention of Dental Biofilm Formation and Immunomodulatory Capacity.
Pharmacogn Mag
May 2016
Background: Caries and periodontal diseases remain as important diseases in the Brazilian population. One important pathogen associated with this situation is Streptococcus mutans and other important factor is this pathogen's ability to adhere firmly to the tooth surface leading to dental biofilm formation and caries development.
Objectives: Determine the antibacterial and other biological activities of P.
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-alpha production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.
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