Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin.

Natural compounds with pharmacological activity, flavonoids have been the subject of an exponential increase in studies in the field of scientific research focused on therapeutic purposes due to their bioactive properties, such as antioxidant, anti-inflammatory, anti-aging, antibacterial, antiviral, neuroprotective, radioprotective, and antitumor activities. The biological potential of flavonoids, added to their bioavailability, cost-effectiveness, and minimal side effects, direct them as promising cytotoxic anticancer compounds in the optimization of therapies and the search for new drugs in the treatment of cancer, since some extensively antineoplastic therapeutic approaches have become less effective due to tumor resistance to drugs commonly used in chemotherapy. In this review, we emphasize the antitumor properties of tangeretin, a flavonoid found in citrus fruits that has shown activity against some hallmarks of cancer in several types of cancerous cell lines, such as antiproliferative, apoptotic, anti-inflammatory, anti-metastatic, anti-angiogenic, antioxidant, regulatory expression of tumor-suppressor genes, and epigenetic modulation.

"K-Powder" Exposure during Adolescence Elicits Psychiatric Disturbances Associated with Oxidative Stress in Female Rats.

Ketamine, also called 'K-powder' by abusers, an analog of phencyclidine, primarily acts as an antagonist of N-methyl-D-aspartic acid (NMDA) receptors, therapeutically used as an anesthetic agent. Ketamine also stimulates the limbic system, inducing hallucinations and dissociative effects. At sub-anesthetic doses, ketamine also displays hallucinatory and dissociative properties, but not loss of consciousness.

Enhancement of the catalytic activity of Mg/Al layered double hydroxide for glycerol oligomers production.

In this study, the impact of rehydration on the catalytic properties of Mg/Al layered double hydroxides (LDH) for glycerol oligomerization was assesed. Although previous works have employed other LDH derived materials in this reaction, little information on recyclability is published. After observing the initial results on how basicity and surface area were related to the catalytic activty, an LDH modification strategy was developed with the addition of acetic acid.

Scheduling deferrable electric appliances in smart homes: a bi-objective stochastic optimization approach.

In the last decades, cities have increased the number of activities and services that depends on an efficient and reliable electricity service. In particular, households have had a sustained increase of electricity consumption to perform many residential activities. Thus, providing efficient methods to enhance the decision making processes in demand-side management is crucial for achieving a more sustainable usage of the available resources.

[Prostate cancer and COVID-19 pandemia: Current recommendations.].

Objective: The objective of this publicationis to provide recommendations in the management of prostate cancer (PC) in a new reality framework based on the presence of COVID-19 disease.

Material And Methods: The document is based on the scarce evidence on SARS/Cov-2 and the experience of the authors in handling COVID-19 in their institutions, including specialists from Andalusia, Cantabria, Catalonia, Madrid and the Valencian Community.

Results: The authors defined different priorities for the different clinical situations in PC.

Anterolateral S1 screw malposition detected with intraoperative neurophysiological monitoring during posterior lumbosacral fusion.

Background: The standard of care is to utilize intraoperative neurophysiological monitoring (IOM) of triggered electromyography (tEMG) during posterior lumbosacral instrumented-fusion surgery. IOM should theoretically signal misplacement of S1 screws into the neural L5-S1 foramen or spinal canal, utilizing screw stimulation, and recording of the lower limb muscles and the anal sphincter. Here, we evaluated when and whether anterolateral S1 screw malposition could be detected by IOM/tEMG during open posterior lumbosacral instrumented fusion surgery.

Traumatic spondyloptosis of L3 with incomplete neurological involvement: A case report.

Unlabelled: High-energy traumas frequently result in lumbar spine fractures such as spondyloptosis is the maximum expression of instability and severity. The management of spondyloptosis is complex and, essentially, surgical. It usually presents with irreversible neurological compromise.

Upper thoracic dumbbell-shaped tumor resected in one stage posterior approach: case report.

Upper thoracic tumors may develop spinal cord compression. By surgery at the time of diagnosis, a neurological deficit can be avoided. However, this particular localization requires a double approach to decompress the spinal cord and thoracic structures.

Natural and Modified Montmorillonite Clays as Catalysts for Synthesis of Biolubricants.

In this study, natural and modified clays were evaluated as catalysts in an esterification reaction to obtain bio-based lubricants. The biolubricants are environmentally preferred to petroleum-based lubricants because they are biodegradable and non-toxic. Other advantages include very low volatility due to the high molecular weight and excellent viscosity properties with temperature variations.

Reproductive pattern of Cuban women living in the municipality of Plaza de la Revolución, Havana, Cuba.

This paper assesses the reproductive and abortion patterns of women living in Plaza de la Revolución, a municipality of Havana, Cuba, by studying the factors influencing birth and abortion rates. Socio-demographic data and female reproductive histories were collected in a survey of 1200 post-menopausal women living in the municipality. Average ages at menarche and at menopause were 12.

Effects of parental reproductive behavior on offspring sex ratio in a pre-industrial western Mediterranean population (La Alpujarra, 1900-1950, SE Spain).

The reproductive behavior of parents of La Alpujarra (Spain) favorable to male offspring during the first half of the 20th century has been studied is this paper. The family size increased as daughters accumulated because mothers had more pregnancies in order to have higher male offspring, and the reproductive rhythm increased (birth interval decreased) when the first deliveries were only daughters. Although male mortality was higher than female in children older than one year, this reproductive behavior did not determine sex reversal of mortality in babies of between one month and one year, contrary to other developing populations.

Polymorphisms influencing muscle phenotypes in North-African and Spanish populations.

Aim: The purpose of this study was to determine the allelic and genotypic frequency distribution of the C34T mutation in the muscle isoform of the adenosine monophosphate deaminase 1 (AMPD1) gene and of the missense substitution K153R in the myostatin (GDF8) gene in one Spanish and two North African populations.

Method: One sample of 98 individuals was genotyped from the South of Spain (Alpujarra) and two samples from Morocco (77 Berbers and 78 Arabs).

Results: The frequency of the AMPD1 C34T mutation was lower in Berbers (0.

Biological fitness and action opportunity of natural selection in an urban population of Cuba: Plaza de la Revolución, Havana.

This paper describes the biological fitness of an urban population of Havana city, Plaza de la Revolución, which has the lowest fertility and the highest demographic ageing in Cuba. The aim is to assess the biological fitness of this community through the indexes of action opportunity of natural selection, to determine its evolutionary pattern and the influence of its socio-cultural peculiarity. Demographic data were obtained from the reproductive histories of 1200 women between the ages of 55 and 64.

Las Alpujarras region (South East Spain) HLA genes study: evidence of a probable success of 17th century repopulation from North Spain.

Conquest of Granada Muslim Kingdom (1492 AD) finished with Muslim occupation; they were mostly North African Berbers who had reached Iberia by 711 AD. A politics of Iberian Christianization followed after this date: Jewish were expelled in 1492 and Moriscos (Spaniards practicing Muslim religion or speaking Arab) were expelled from all Spanish territory on 1609 AD. Las Alpujarras is a southern Spain mountainous secluded region, which underwent a repopulation from North Spain and a specific Muslim (Moriscos)-Christian war took place according to historical records.

CYP2D6 polymorphism screening in a selected population of Spain (La Alpujarra): no effect of geographical isolation.

Background: There is growing interest in the CYP2D6 gene because of its key role in the metabolism of numerous commonly used drugs.

Aim: We compared the frequency of the most frequent null CYP2D6 alleles (CYP2D6*3, CYP2D6*4,CYP2D6*5, CYP2D6*6, CYP2D6*7 and CYP2D6*8) between individuals from the Spanish population and from La Alpujarra.

Subjects And Methods: The present study comprises Spanish cohort (n = 185) and from La Alpujarra (n = 104).

STR genetic diversity in a Mediterranean population from the south of the Iberian Peninsula.

Sixteen Y-chromosomal short tandem repeats (STRs) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635 and GATA H4.1) were typed in DNA samples from 52 unrelated men and 15 autosomal STRs (CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, TH01, TPOX, vWA) were also studied for a group of 90 individuals (men and women) from the same population (Andalusians from La Alpujarra, South of Spain). The Alpujarrenian population represents an example of an isolated population with remarkable geographical, cultural and historical characteristics.

Population relationships in the Mediterranean revealed by autosomal genetic data (Alu and Alu/STR compound systems).

The variation of 18 Alu polymorphisms and 3 linked STRs was determined in 1,831 individuals from 15 Mediterranean populations to analyze the relationships between human groups in this geographical region and provide a complementary perspective to information from studies based on uniparental markers. Patterns of population diversity revealed by the two kinds of markers examined were different from one another, likely in relation to their different mutation rates. Therefore, while the Alu biallelic variation underlies general heterogeneity throughout the whole Mediterranean region, the combined use of Alu and STR points to a considerable genetic differentiation between the two Mediterranean shores, presumably strengthened by a considerable sub-Saharan African genetic contribution in North Africa (around 13% calculated from Alu markers).

Child age influence on the seasonal death risk during the first year of life (Spain, 1975-1989).

Infant mortality rate reflects a population's health status, which depends on several factors, such as diseases, environment, child development, and other population characteristics that can show seasonal change throughout the year. This article deals with the relevance of child age on the probability of death in the different seasons throughout the first year of life, taking into account the illnesses causing death. The study was carried out using a file from the Spanish National Institute of Statistics.

Life expectancy in a western and immigrant receiving population (El Ejido, SE Spain).

This study deals with the mortality pattern of El Ejido population, an agricultural Spanish community with a sub-tropical climate, located on the western Mediterranean coast (Andalusia). Based on the incorporation of modern agrarian techniques, this region has experienced a great economic development. Its demographic consequences were relevant, such as the arrival of immigrants throughout the second half of the twentieth century.

Causes of neonatal mortality in Spain (1975-98): influence of sex, rural-urban residence and age at death.

Neonatal mortality during the first week of life, corresponding to the years 1975-1998, was studied in Spain. The first week of life is the time in which the highest number of deaths occur. The temporal decrease of the neonatal mortality rate (NMR) was modelled according to log10(NMR+1)= 2.

Acupuncture and rehabilitation of the painful shoulder: study protocol of an ongoing multicentre randomised controlled clinical trial [ISRCTN28687220].

Background: Although the painful shoulder is one of the most common dysfunctions of the locomotor apparatus, and is frequently treated both at primary healthcare centres and by specialists, little evidence has been reported to support or refute the effectiveness of the treatments most commonly applied. According to the bibliography reviewed, physiotherapy, which is the most common action taken to alleviate this problem, has not yet been proven to be effective, because of the small size of sample groups and the lack of methodological rigor in the papers published on the subject. No reviews have been made to assess the effectiveness of acupuncture in treating this complaint, but in recent years controlled randomised studies have been made and these demonstrate an increasing use of acupuncture to treat pathologies of the soft tissues of the shoulder.

Reproductive pattern in agrarian and immigrant receptor populations: a survey of El Ejido (SE Spain).

This paper deals with the fertility pattern of the El Ejido population, an agricultural Spanish community characterised by the rapid development of its modern agrarian economy. Consequently, the arrival of immigrants has sharply increased throughout the second half of the twentieth century, with important demographic consequences as well as reproductive changes. The analyses of the age-specific fertility rate (fx) and the total fertility rate (TFR) were used in order to describe the reproductive pattern of this population in 2000.