Age at onset in bipolar I disorder: two may be better than three subgroups.

Introduction And Objective: Age at onset in bipolar disorder is related to prognosis and to treatment response. However, it is not clear if there are three or two subgroups in relation to age at onset. The objective of this study is to analyze the number of subgroups in relation to age at the beginning of the disease in a representative sample of bipolar I patients and to compare the subgroups in relation to clinical variables.

[Changes of physical and functional characteristics in soccer players].

Unlabelled: The purpose of this study was to examine the trends in selected physical cardiovascular and metabolic variables in 248 first division professional soccer players within a period of 27 years (1973-2000).

Method: In a cross sectional study (panel) 198 Mexican players and 50 mainly from Brazil and Argentina were evaluated for physical examination, body composition, blood samples, EKG and maximal oxygen uptake on a treadmill. Data were categorized by decade (70's n = 66, 80's n = 84 and 90's n = 98) and analyzed for significant differences by ANOVAS (p < 0.