Publications by authors named "Francisco Javier Meza Cadavid"
Hematol Rep
February 2023
Article Synopsis
- The narrative review aims to enhance understanding of hemophilia A, a genetic disease that significantly affects the quality of life and is costly for health systems, particularly noted as one of the top economic burdens in Colombia.
- The review highlights the shift towards precision medicine in treating hemophilia, emphasizing the importance of genetic, pharmacokinetic, and environmental factors that affect treatment efficacy.
- Building robust scientific evidence with strong statistical backing is essential to personalize treatment approaches in a cost-effective manner.
Article Synopsis
- * The study included 12 patients with severe hemophilia A, aged 6 to 48, and found that 50% had an inversion of intron 22, which is associated with a higher risk of developing inhibitors.
- * Results showed that 83.3% of patients had null mutations, with 66.7% presenting high inhibitor titers, suggesting a need for further research on how these mutations impact treatment effectiveness and coagulation factors.
