Publications by authors named "Francisco Javier Martin de Carpi"
Background: Active disease during conception and pregnancy in women with inflammatory bowel disease (IBD) increases the risk of pregnancy complications and adverse neonatal outcomes. The use of IBD treatments during pregnancy should be weighed against their adverse effects on the neonate, but longer-term safety data and data on serious infection rates and malignancies postnatally are lacking, particularly for newer drugs, such as tofacitinib, vedolizumab and ustekinumab.
Methods: This ongoing, prospective registry study being conducted at 70 centres in Spain is enrolling pregnant women who are ⩾18 years, are at any point in pregnancy up to the end of the second trimester and have a diagnosis of Crohn's disease, ulcerative colitis or unclassified IBD.
Article Synopsis
- The study aimed to update the ECCO-ESPGHAN guidelines for the medical management of pediatric Crohn's disease by developing 17 clinical questions and conducting a systematic literature search from 1991 to 2019.
- A consensus meeting refined 30 preliminary statements into 22 that achieved over 80% agreement, focusing on identifying high-risk patients and optimizing treatment strategies.
- Key recommendations include using anti-TNF agents for severe cases, exclusive enteral nutrition for low-risk patients, and regular monitoring through faecal calprotectin or imaging to adjust treatments effectively.