Anisotropic Porous Iron-Based Nanoparticles through Two-Step Hydrothermal and Hydrogen-Based Reduction: Enhanced Magnetic Performance for Potential Biomedical Applications.

Iron-based nanoparticles have emerged as promising candidates for diverse biomedical applications, including cell separation, targeted drug delivery, hyperthermia therapy, and magnetic resonance imaging. This study reports the scalable synthesis of high-magnetization iron-based nanoparticles with controlled anisotropic shapes, achieved via a two-step process. Hematite nanoparticles, featuring nanocube, nanoellipse, and nanoneedle morphologies, were synthesized through the hydrolysis of ferric chloride in the presence of ammonium dihydrogen phosphate, with the morphology precisely tuned by adjusting reagent concentrations.