Can fibrinolytic system components explain cognitive impairment in multiple sclerosis?

Background: The fibrinolytic system is capable of modulating inflammatory and degenerative events within the central nervous system. Specifically, the plasminogen activator inhibitor-1 (PAI-1) has been associated with different pathological conditions in multiple sclerosis (MS) and its role in cognitive functioning is also known.

Objectives And Methods: To study the association between plasma levels and the polymorphic variants of the PAI-1 gene and cognitive performance in MS.