Publications by authors named "Francisco Javier Avelar Gonzalez"

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  • Aguascalientes has a high rate of kidney failure in young adults, potentially linked to low kidney volume (KV) at birth and exposure to harmful substances (xenobiotics).
  • The study involved 299 healthy pregnant women, analyzing their urine, amniotic fluid, and their newborns' urine to measure various toxic metals and pesticides, alongside calculating the total kidney volume.
  • Results indicated that exposure to specific pesticides and fluoride during pregnancy correlated with low kidney volume in infants, suggesting a possible connection to kidney health issues and electrolyte imbalances.
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  • - The study investigates how different extraction methods (Soxhlet, maceration, ultrasound-assisted) influence the phytochemical profile and antioxidant activity of guava leaf extracts, which are rich in polyphenolic compounds.
  • - The extraction yield of phenolic compounds ranged from 16 to 45 mg/g, with the Soxhlet method producing the strongest antioxidant effects based on various assays (ABTS, FRAP, Folin-Ciocalteu).
  • - Key bioactive compounds such as quercetin, kaempferol, and avicularin were identified, highlighting that both the method of extraction and purification significantly enhance the antioxidant capacity of guava leaf extracts.
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Uropathogenic (UPEC) strains are among the leading causes of urinary tract infections (UTIs) worldwide. They can colonize the urinary tract and form biofilms that allow bacteria to survive and persist, causing relapses of infections and life-threatening sequelae. Here, we analyzed biofilm production, antimicrobial susceptibility, virulence factors, and phylogenetic groups in 74 isolated from diagnosed patients with UTIs to describe their microbiological features and ascertain their relationship with biofilm capabilities.

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A molecular characterization of the main phytochemicals and antioxidant activity of (OR) fruit extract was carried out, as well as an evaluation of its hepatoprotective effect against diclofenac (DF)-induced acute liver injury was evaluated. Phenols, flavonoids and betalains were quantified, and antioxidant characterization was performed by means of the ABTS, DPPH and FRAP assays. UPLC-QTOF-MS/MS was used to identify the main biocompounds present in OR fruit extract was carried out via.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of Coronavirus disease 2019 (COVID-19), a pandemic disease declared in 2020. The clinical manifestations of this pathology are heterogeneous including fever, cough, dyspnea, anosmia, headache, fatigue, taste dysfunction, among others. Survivors of COVID-19 have demonstrated several persistent symptoms derived from its multisystemic physiopathology.

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  • - The study investigates the high prevalence of end-stage renal failure of unknown origin (ESRD-UO) among adolescents in Aguascalientes, Mexico, particularly affecting 20-40 year-olds, by screening for chronic kidney disease (CKD) and identifying associated risk factors.
  • - In analyzing 513 students, the research found that 3.7% exhibited persistent albuminuria, though there were no significant homeostatic or anatomical abnormalities detected through renal ultrasound; however, those with albuminuria did show reduced total renal volume.
  • - Kidney biopsies revealed glomerulomegaly and various podocyte abnormalities, with identified risk factors linked to environmental exposures and family health history, while a higher BMI and breastfeeding appeared
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  • Staphylococcus aureus and Candida albicans often coexist in biofilm-related infections (like denture stomatitis and periodontitis), but their combined biofilm characteristics aren't fully understood.
  • The study aimed to explore the biofilm density, synergy, composition, structure, and stability of these two microorganisms against antimicrobial measures.
  • Results indicated that fetal bovine serum (FBS) reduced biofilm formation for S. aureus, while glucose or FBS positively influenced C. albicans growth, with C. albicans acting as a structural scaffold for S. aureus adherence in their complex biofilm.
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  • The study investigates how ApxI, a toxin from Actinobacillus pleuropneumonia, induces rapid cell death in porcine alveolar macrophages and endothelial cells through a process called pyroptosis, which is dependent on the NLRP3 inflammasome and caspase-1 activation.
  • Researchers used various inhibitors to block caspase-1 and the NLRP3 inflammasome, finding that these treatments reduced cell death caused by ApxI, indicating the involvement of these pathways in the cell death process.
  • The findings reveal that ApxI triggers pyroptosis in alveolar macrophages for the first time, highlighting the significant role of the N
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Urinary tract infections (UTIs) affect more than 150 million people, with a cost of over 3.5 billion dollars, each year. is associated with 70-80% of UTIs.

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A total of sixteen composite soil and sediment samples were collected during the rainy and dry season in Asientos, Aguascalientes, Mexico, an area recently affected by increased mining operations. Physicochemical characterization showed that substrates were moderately to strongly calcareous with predominantly neutral to slightly alkaline pH, moderate to high cation-exchange capacity and high organic matter content. Due to these conditions, Cd, Pb, Cu and Zn were not water leachable despite high concentrations; up to 105.

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Waterborne pathogens and related diseases are a major public health concern worldwide, not only by the morbidity and mortality that they cause, but by the high cost that represents their prevention and treatment. These diseases are directly related to environmental deterioration and pollution. Despite the continued efforts to maintain water safety, waterborne outbreaks are still reported globally.

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Wastewater discharges into freshwater bodies represent a serious ecological problem worldwide. In underdeveloped and developing countries wastewater treatment plants (WTP) only count with basic treatment, leading to the pollution of important aquatic reservoirs causing critical situations. In the present work, a one year evaluation of toxicity and main physical and chemical parameters of one of the major WTP of the state of Aguascalientes was conducted fortnightly, and to assess treatment alternatives for this WTP we tested: a) three white rot fungi (WRF), b) a photo-electrochemical process, c) ion-exchangers resins and activated carbon.

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A new system for sustained release of growth factors, such as osteogenic protein 1 (OP-1) and transforming growth factor β1 (TGF-β1), intended to repair and promote dental tissue regeneration in rats was designed and characterized in this work. The release system was made with microparticles of sodium alginate, produced by ionic gelling dripping technique. The release profiles of OP-1 and TGF-β1 from biopolymer matrix were determined by high-performance liquid chromatography (HPLC), and with this purpose, an HPLC-UV method was developed.

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Odontogenesis is extensively studied in animal models but less understood in human. In early amelogenesis, amelogenin constitutes 90% of enamel organic matrix, which is degraded by enamelysin and replaced by hydroxyapatite crystals. Here, amelogenin and enamelysin distribution changes during amelogenesis were shown by co-localization experiments by confocal microscopy.

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Forty-eight hours acute toxicity tests were employed with Daphnia magna and Lecane quadridentata to assess the influents and effluents of the seven most important wastewater treatment plants (WTP) in the state of Aguascalientes, Mexico, during the 2006 dry and rainy seasons. The WTP of the City of Aguascalientes treated 1948 Ls(-1). The remaining six plants treated wastewater in the range from 28 to 93 Ls(-1).

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An environmental study revealed that three metals (Al, Fe and Zn) are common in the San Pedro River (SPR) (Aguascalientes, Mexico). Regrettably, in many samples the concentrations of these metals exceeded the maximum allowed toxicant concentrations levels as defined in by Mexican legislation. The highest concentrations of the three metals were found during the 2005 dry season, with elevated Al concentrations present along the entire river.

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