Publications by authors named "Francisco J de Castro"

Article Synopsis
  • The study aimed to systematically review and assess the effectiveness of sentinel lymph-node biopsy (SLNB) in women with node-positive breast cancer diagnosed and node-negative tumors after neoadjuvant therapy, comparing it to axillary lymph-node dissection.
  • Key metrics analyzed included false-negative rate (FNR), sentinel lymph-node identification rate (SLNIR), negative predictive value (NPV), and overall accuracy through data from twenty relevant studies.
  • Results showed that SLNB had a low FNR of 0.14 and high SLNIR of 0.89, indicating better outcomes especially when multiple nodes were removed and double mapping techniques were used.
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Purpose: We conducted a systematic review to analyse the performance of the sentinel lymph-node biopsy (SLNB) after the neoadjuvant chemotherapy, compared to axillary lymph-node dissection, in terms of false-negative rate (FNR) and sentinel lymph-node identification rate (SLNIR), sensitivity, negative predictive value (NPV), need for axillary lymph-node dissection (ALND), morbidity, preferences, and costs.

Methods: MEDLINE, Embase, Scopus, and The Cochrane Library were searched. We assessed the quality of the included systematic reviews using AMSTAR2 tool, and estimated the degree of overlapping of the individual studies on the included reviews.

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Background: Thyroid metastases are extremely rare, with an incidence of 1-3% according to different data. Colon cancer is the second most common tumor that metastasizes to this organ.

Case Report: We report a case of a long-standing colon cancer with an atypical metastatic pattern and the appearance of a thyroid metastases.

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We present a clinical case of a solitary fibrous pleural tumor (TFSP) with abnormal behavior due to its high aggressiveness and poor short-term prognosis, where an ALK translocation was identified. TFSP is an infrequent tumor, with an estimated incidence of around 8 per 100,000 inhabitants and with few cases reported in the literature. The most common is that it is a neoplasm of benign behavior, with debut as a localized mass and whose The treatment of choice is surgical resection.

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During sugar cane harvesting season, which occurs from May to November of each year, the crops are burnt, cut, and transported to the mills. There are reports showing that mutagenic activity and PAH content increase during harvesting season in some areas of São Paulo State in comparison with nonharvesting periods. The objective of this work was to preliminarily characterize the mutagenic activity of the total organic extracts as well as corresponding organic fractions of airborne particulate matter (PM) collected twice from two cities, Araraquara (ARQ) and Piracicaba (PRB), during sugar cane harvesting season using the Salmonella/microsome microssuspension assay.

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Background: Because nonsteroidal anti-inflammatory drug (NSAID) intolerance depends on COX-1 inhibition, preferential or selective COX-2 inhibitors have been thought to be well tolerated by these patients.

Objective: The aim of this study is to evaluate tolerability to nabumetone and meloxicam in patients with NSAID intolerance.

Methods: Seventy patients intolerant to NSAIDs were selected.

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The ability of photoelectrocatalytic oxidation to degrade the commercially important copper-phtalocyanine dye, remazol turquoise blue 15 (RTB) was investigated. The best experimental condition was optimized, evaluating the performance of Ti/TiO2 thin-film electrodes prepared by sol-gel method in the decolourization of 32 mg L(-1) RTB dye in 0.5 mol L(-1) Na2SO4 pH 8 and applied potential of +1.

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