Publications by Francisco J Hermoso

Publications by authors named "Francisco J Hermoso"

Eur J Med Chem

September 2018

* Using a lead compound (4b), researchers synthesized a new series of analogs, with the best calpain I inhibitor found to be significantly more potent than 4b, showing an IC value of 20 nM.
* Compound 4b exhibited uncompetitive inhibition without causing cellular toxicity and was effective in blocking chemical-induced apoptosis in human kidney cells by preventing calpain activation.

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