Publications by authors named "Francisco J Anglada"
Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool.
Mol Ther Nucleic Acids
March 2022
Prostate-specific antigen (PSA) is the gold-standard marker to screen prostate cancer (PCa) nowadays. Unfortunately, its lack of specificity and sensitivity makes the identification of novel tools to diagnose PCa an urgent medical need. In this context, microRNAs (miRNAs) have emerged as potential sources of non-invasive diagnostic biomarkers in several pathologies.
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- * Researchers investigated the relationship between urine In1-ghrelin levels and various metabolic factors (like obesity and diabetes) to determine its clinical relevance in assessing PCa risk among patients with ambiguous PSA results.
- * The findings show that In1-ghrelin levels are significantly higher in PCa patients, correlating with increased cancer risk and aggressiveness, and enhancing the diagnostic accuracy of existing clinical models.
Objective: To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL).
Patients And Methods: Prospective, randomised, double-blind, placebo-controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL. The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after.