Beyond digestive pathology: endoscopic study in systemic disease.

A 77-year-old male patient with heart disease, kidney disease under study, and quiescent multiple myeloma. He presented a 2 years history of weight loss and digestive symptoms. In the endoscopic study, multiple gastric ulcers were observed, whose histological study ruled out the initial suspicion.

Efficacy and safety of tofacitinib in the treatment of ulcerative colitis: real-life experience in Andalusia.

Background: tofacitinib is a Janus kinase inhibitor approved for the treatment of moderate-severe ulcerative colitis (UC). This study aimed to evaluate its efficacy in a real-life setting.

Methods: a retrospective and multicenter observational study was performed with UC patients treated with tofacitinib.

Azathioprine-induced alopecia: a rare adverse event, early marker of myelotoxicity.

Though not exempt from adverse events, azathioprine (AZA) is an inexpensive and effective drug in the induction and maintenance treatment of patients with inflammatory bowel disease. We present the case of a 20-year-old female patient with left-side ulcerative colitis in whom AZA was started at a dose of 1.5 mg/kg/day due to dependence on corticoids (thiopurine methyltransferase activity: 14.

Percutaneous endoscopic gastrostomy. Indications, care and complications.

Percutaneous endoscopic gastrostomy (PEG) is an effective and safe method for nutritional support in patients with malnutrition and impossibility of oral intake with an estimated survival higher than the months that require enteral nutrition beyond four weeks. The main indications include neoplasms of the upper air-digestive tract and neurological diseases, with dementia currently considered a controversial indication. Anatomical alterations and infectious diseases are the most frequent contraindications.

Intestinal tuberculosis and Crohn's disease: the importance and difficulty of a differential diagnosis.

Tuberculosis (TB) is the most prevalent infection worldwide and affects one third of the population, predominantly in developing countries. Intestinal TB (ITB) is the sixth most frequent extra-pulmonary TB infection. Crohn's disease (CD) is a chronic inflammatory bowel disease that arises from the interaction of immunological, environmental and genetic factors.

Initial experience with golimumab in clinical practice for ulcerative colitis.

Background: Golimumab is a TNF-blocking agent indicated as a second-line therapy in ulcerative colitis.

Purpose: To research the effectiveness and safety of golimumab in patients with ulcerative colitis in clinical practice.

Methods: Retrospective study of the effectiveness and safety of golimumab in patients with ulcerative colitis.

[Multiple splenic abscesses].

Multiple splenic abscesses is a rare condition in the clinical practice encountered mostly in immunocompromised patients. We report the case of a 81 year old male admitted to the hospital for fever, abdominal pain and jaundice. An abdominal ultrasound and computed tomography demonstrated multiple splenic abscesses.