Publications by authors named "Francisco Frias"
Article Synopsis
- * A sample of 401 schoolchildren revealed significant associations between different types of ACEs (like bullying and sexual abuse) and PTSD/CPTSD diagnoses, with fearful attachment styles also playing a role.
- * The findings highlight the need to prioritize addressing childhood trauma in public health initiatives in Uganda, as biological, psychological, and social factors interplay in the impact of ACEs on mental health.
Background: Severe forms of alpha(1)-antitrypsin (AAT) deficiency require augmentation therapy by intravenous administration of purified preparations of AAT concentrate. Although standard AAT treatment schedules are widely available, pharmacokinetic studies characterizing AAT serum decay are scarce, and data on the variability of individual patients are almost nonexistent.
Objective: To establish individual AAT pharmacokinetics and develop a predictive model based on simple pharmacokinetic characterization that can be used to optimize individual AAT dosing regimens.
Angiotensin-converting enzyme i/d polymorphism in patients with malignant hypertension.
J Clin Hypertens (Greenwich)
January 2005
The angiotensin-converting enzyme (ACE) gene has been implicated in the manifestation of the phenotype of malignant hypertension (MH). In 1990 the ACE gene polymorphism characterized by the insertion or deletion of a 287-base pair fragment in the 17q23 chromosome was identified. The DD genotype is associated with increased tissue and circulating ACE levels and elevated angiotensin II.
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