Drivers of urban biodiversity in Mexico and joint risks from future urban expansion, climate change, and urban heat island effect.

Urbanization is a phenomenon where humans concentrate in high densities and consume more per capita energy than in rural areas, imposing high pressures on biodiversity and ecosystem services. Although Mexico is recognized as a megadiverse country and there is an understanding of ecological and evolutionary processes underlying this high diversity, only some efforts have been devoted to understanding how urban biodiversity has been shaped. Here, we compiled a set of socioeconomic and ecological variables to explore macroecological patterns in urban biodiversity across Mexican municipalities.

On the persistence of near-surface temperature dynamics in a warming world.

We consider issues related to the effect of climate change on the persistence of (trend-corrected) temperatures using global gridded data for both land and oceans. We first discuss how the presence of trends and additive noise affects inference about persistence. Ignoring a trend induces an upward bias, while not accounting for noise induces a downward bias.

Anthropogenic influence on extremes and risk hotspots.

Study of the frequency and magnitude of climate extremes as the world warms is of utmost importance, especially separating the influence of natural and anthropogenic forcing factors. Record-breaking temperature and precipitation events have been studied using event-attribution techniques. Here, we provide spatial and temporal observation-based analyses of the role of natural and anthropogenic factors, using state-of-the-art time series methods.

Toward New Epidemiological Landscapes of (Kinetoplastida, Trypanosomatidae) Transmission under Future Human-Modified Land Cover and Climatic Change in Mexico.

Chagas disease, caused by the protozoa , is an important yet neglected disease that represents a severe public health problem in the Americas. Although the alteration of natural habitats and climate change can favor the establishment of new transmission cycles for the compound effect of human-modified landscapes and current climate change on the transmission dynamics of has until now received little attention. A better understanding of the relationship between these factors and presence is an important step towards finding ways to mitigate the future impact of this disease on human communities.

Impacts of land management and climate change in a developing and socioenvironmental challenging transboundary region.

Land-use/cover change is the major cause of terrestrial ecosystem degradation. However, its impacts will be exacerbated due to climate change and population growth, driving agricultural expansion because of higher demand of food and lower agricultural yields in some tropical areas. International strategies aimed to mitigate impacts of climate change and land use-cover change are challenging in developing regions.

Disentangling the trend in the warming of urban areas into global and local factors.

Large cities account for a significant share of national population and wealth, and exert high pressure on local and regional resources, exacerbating socioenvironmental risks. The replacement of natural landscapes with higher heat capacity materials because of urbanization and anthropogenic waste heat are some of the factors contributing to local climate change caused by the urban heat island (UHI) effect. Because of synergistic effects, local climate change can exacerbate the impacts of global warming in cities.

Economic impacts and risks of climate change under failure and success of the Paris Agreement.

The Nationally Determined Contributions (NDCs) represent the world's first effort toward the Paris Agreement goal of keeping global temperature increase well below 2 °C and pursuing 1.5 °C. Little is known about how much the proposed mitigation efforts can reduce the risks and economic damages from unabated climate change and about the consequences if key emitters drop the Paris Agreement.

Synergistic impacts of global warming and thermohaline circulation collapse on amphibians.

Impacts on ecosystems and biodiversity are a prominent area of research in climate change. However, little is known about the effects of abrupt climate change and climate catastrophes on them. The probability of occurrence of such events is largely unknown but the associated risks could be large enough to influence global climate policy.

Spatial variations in the warming trend and the transition to more severe weather in midlatitudes.

Due to various feedback processes called Arctic amplification, the high-latitudes' response to increases in radiative forcing is much larger than elsewhere in the world, with a warming more than twice the global average. Since the 1990's, this rapid warming of the Arctic was accompanied by no-warming or cooling over midlatitudes in the Northern Hemisphere in winter (the hiatus). The decrease in the thermal contrast between Arctic and midlatitudes has been connected to extreme weather events in midlatitudes via, e.

Causality from long-lived radiative forcings to the climate trend.

In our study, we present a purely statistical observations-based model-free analysis that provides evidence about Granger causality (GC) from long-lived radiative forcings (LLRFs) to the climate trend (CT). This relies on having locally ordered breaks in the slopes of the trend functions of LLRF and the CT, with the break for LLRF occurring before that of the CT and with the slope changes being of the same sign. The empirical evidence indicates that these conditions are satisfied empirically using standard global surface temperature series and an aggregate measure of LLRF (carbon dioxide, nitrous oxide, and chlorofluorocarbons).

Global economic impacts of climate variability and change during the 20th century.

Estimates of the global economic impacts of observed climate change during the 20th century obtained by applying five impact functions of different integrated assessment models (IAMs) are separated into their main natural and anthropogenic components. The estimates of the costs that can be attributed to natural variability factors and to the anthropogenic intervention with the climate system in general tend to show that: 1) during the first half of the century, the amplitude of the impacts associated with natural variability is considerably larger than that produced by anthropogenic factors and the effects of natural variability fluctuated between being negative and positive. These non-monotonic impacts are mostly determined by the low-frequency variability and the persistence of the climate system; 2) IAMs do not agree on the sign (nor on the magnitude) of the impacts of anthropogenic forcing but indicate that they steadily grew over the first part of the century, rapidly accelerated since the mid 1970's, and decelerated during the first decade of the 21st century.

Prevalent HLA Class II Alleles in Mexico City Appear to Confer Resistance to the Development of Amebic Liver Abscess.

Amebiasis is an endemic disease and a public health problem throughout Mexico, although the incidence rates of amebic liver abscess (ALA) vary among the geographic regions of the country. Notably, incidence rates are high in the northwestern states (especially Sonora with a rate of 12.57/100,000 inhabitants) compared with the central region (Mexico City with a rate of 0.

Severe postpartum hemorrhage from uterine atony: a multicentric study.

Objective: Postpartum hemorrhage (PPH) is an important cause of maternal mortality (MM) around the world. Seventy percent of the PPH corresponds to uterine atony. The objective of our study was to evaluate multicenter PPH cases during a 10-month period, and evaluate severe postpartum hemorrhage management.

A time-series analysis of the 20th century climate simulations produced for the IPCC's Fourth Assessment Report.

In this paper evidence of anthropogenic influence over the warming of the 20th century is presented and the debate regarding the time-series properties of global temperatures is addressed in depth. The 20th century global temperature simulations produced for the Intergovernmental Panel on Climate Change's Fourth Assessment Report and a set of the radiative forcing series used to drive them are analyzed using modern econometric techniques. Results show that both temperatures and radiative forcing series share similar time-series properties and a common nonlinear secular movement.

Altered calcium pump and secondary deficiency of gamma-sarcoglycan and microspan in sarcoplasmic reticulum membranes isolated from delta-sarcoglycan knockout mice.

Sarcoglycans (SGs) and sarcospan (SSPN) are transmembrane proteins of the dystrophin-glycoprotein complex. Mutations in the genes encoding SGs cause many inherited forms of muscular dystrophy. In this study, using purified membranes of wild-type (WT) and delta-SG knockout (KO) mice, we found the specific localization of the SG-SSPN isoforms in transverse tubules (TT) and sarcoplasmic reticulum (SR) membranes.

A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle.

The sarcoglycan-sarcospan complex (alpha-, beta-, gamma-, delta-, epsilon-, and zeta-SG-SSPN), a component of the dystrophin-associated glycoprotein complex (DAGC), is located at the sarcolemma of muscle fibers where it contributes to maintain cell integrity during contraction-relaxation cycles; gamma- and delta-SG are also expressed in the sarcoplasmic reticulum (SR). In this study, we report the identification of a novel isoform of murine delta-SG produced by alternative splicing that we named delta-SG3. This isoform is present at transcript level in several tissues, with its highest expression in skeletal and cardiac muscle.

Molecular demonstration of SLC4A1 gene deletion in two Mexican patients with Southeast Asian ovalocytosis.

We describe the finding of two Mexican patients with a specific 27-bp deletion in the solute carrier family 4 gene (SLC4A1delta27) (also known as the band 3 gene found on chromosome 17q21-q22), characteristic of Southeast Asian ovalocytosis (SAO). The patients were asymptomatic, and the initial diagnosis was made by microscopic observation of the presence of typical stomatocytic ovalocytes. The gene deletion was confirmed by PCR and DNA sequencing.