Performance of the Idylla microsatellite instability test in endometrial cancer.

Context: DNA mismatch repair (MMR) deficiency (dMMR) testing is now recommended in endometrial cancer. Defect identification in the molecules participating in this pathway, or the presence of microsatellite instability, are commonly employed for this purpose. Novel methods are continuously evolving to report dMMR/microsatellite instability and to easily perform routine diagnoses.

BiotechLec: an interactive guide of commercial lectins for glycobiology and biomedical research applications.

For decades, lectins have been used as probes in glycobiology and this usage has gradually spread to other domains of Life Science. Nowadays, researchers investigate glycan recognition with lectins in diverse biotechnology and clinical applications, addressing key questions regarding binding specificity. The latter is documented in scattered and heterogeneous sources, and this situation calls for a centralized and easy-access reference.

Coenzyme Q10 improves the in vitro maturation of oocytes exposed to the intrafollicular environment of patients on fertility treatment.

Objective: To evaluate the impact of patient follicular environment with oxidative stress on oocyte quality.

Methods: Patients on fertility treatment with either advanced maternal age or endometriosis were asked to donate follicular fluid collected during ovum pick-up. Follicular fluid (FF) was added (20%, 10% and 5%; %V/V) to in vitro maturation (IVM) medium with mouse oocytes.

Oxidative balance in follicular fluid of ART patients of advanced maternal age and blastocyst formation.

Objective: To evaluate the follicular fluid oxidative balance of infertile patients of advanced-maternal-age and the correlation between oxidative imbalance in the follicular fluid and the embryological outcomes.

Methods: Follicular fluid (FF) from infertile patients of advanced-maternal-age undergoing ART treatments were collected and frozen in cryovials at -86°C until further use, and analyzed at the Biochemistry and Nutrition Institute of San Marcos University. As controls, we used FF from oocyte donors.

Contemporary Yield of 24-hour Holter Monitoring: Role of Inter-Atrial Block Recognition.

Background: The diagnostic yield of 24-hour ECG Holter monitoring (24H) is currently overcome by alternative ECG monitoring techniquesand it needs to be optimized. The recognition of inter-atrial block (IAB) has emerged as a reliable indicator of patients at risk of atrial fibrillation relapses, and its role enhancing the yield of 24H is yet to be determined. We hypothesized that a presumably low yield of 24H may be ameliorated by means of incorporating the assessment for IAB.

The Pyramidal Flap: an Innovative Technique for DIEP Flap Refinement.

DIEP flap is considered the gold standard technique for breast reconstruction. One of the most frequent contour deformities after breast reconstruction with DIEP flap is a step-off deformity at the interface between the native chest wall and the reconstructed breast. Different techniques have been used to address this problem.

Occurrence of ovarian follicular dominance during stimulation for IVM impacts usable blastocyst yield.

Objective: To evaluate the influence of ovarian follicular dominance on the outcome of oocyte in-vitro maturation.

Methods: This retrospective cohort study included 21 patients with polycystic ovaries or polycystic ovary syndrome (Rotterdam criteria, 2004) subjected to 24 invitro maturation (IVM) cycles between October 2015 and January 2017. Patients undergoing IVM received minimal gonadotropin stimulation starting on day 2 or 3 of the cycle; ovum pick-up typically occurred on days 6 to 8.

Choroidal metastasis from primary bone leiomyosarcoma.

Choroidal metastases, the most common form of intraocular malignancies, are principally caused by primary tumors from breast, lung, and gastrointestinal tract. These lesions are mostly symptomatic and rarely detected incidentally in the extension study of a previously diagnosed tumor. Leiomyosarcoma is a neoplasm of mesenchymal cells with smooth muscle differentiation and represents the most prevalent soft-tissue sarcoma.

Feasibility of Chlamydia trachomatis screening and treatment in pregnant women in Lima, Peru: a prospective study in two large urban hospitals.

Objectives: Chlamydia trachomatis, which is asymptomatic in most women, causes significant adverse effects for pregnant women and neonates. No programmes conduct antenatal screening in Latin America. We determined chlamydia prevalence, feasibility and acceptability of chlamydia screening, and adherence to treatment in pregnant women in two urban public hospitals in Lima, Peru.

[Prevalence and angiographic significance of normal myocardial perfusion SPECT with positive exercise electrocardiogram].

In a consecutive series of 7350 myocardial perfusion SPECT studies, 66 (0.9%) nonrevascularized patients with a normal resting ECG had normal scintigraphic findings with a positive ECG in the exercise test. We retrospectively analyzed 33 patients with coronary angiography, 26 of whom were women (P< .

Prototype provisional restorations for implant-supported, full-mouth, metal-ceramic reconstructions: the hybrid technique.

The restoration of fully edentulous patients using fixed, metal-ceramic prostheses is one of the most challenging tasks in aesthetic dentistry. Provisional restorations provide the treatment team with a valuable means of addressing criteria that are required throughout the surgical, prosthetic, and technical stages. They also enable the clinician to place and evaluate a prototype of the definitive restoration in the patient's intraoral environment.