Publications by authors named "Francisco E Neal"
Article Synopsis
- The BRCA2 tumor suppressor is essential for repairing DNA double-strand breaks through a process called homologous recombination, specifically involving RAD51 protein.
- Research shows that the C-terminal Recombinase Binding (CTRB) region of BRCA2, found in its exon 27, has DNA-binding capabilities that enhance RAD51's ability to facilitate DNA strand exchange.
- The study highlights the importance of CTRB in protecting DNA replication forks during repair processes, suggesting that loss of this function can lead to serious developmental issues, such as embryonic lethality.
