Publications by authors named "Francisco Carriquiriborde"
Outer membrane vesicles (OMV) derived from the etiologic agent of the resurgent disease called pertussis-are safe and effective in preventing bacterial colonization in the lungs of immunized mice. Vaccine formulations containing those OMV are capable of inducing a mixed Th1/Th2/Th17 profile, but even more interestingly, they may induce a tissue-resident memory immune response. This immune response is recommended for the new generation of pertussis-vaccines that must be developed to overcome the weaknesses of current commercial acellular vaccines (second-generation of pertussis vaccine).
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- Pertussis resurgence is linked to decreased vaccine immunity and bacteria adapting to evade vaccine protection, particularly in countries using the acellular pertussis vaccine.
- Genetic analysis of B. pertussis isolates from Buenos Aires indicates a high prevalence of a specific allelic profile, with very few pertactin-deficient strains present since the adoption of whole-cell vaccines.
- The findings imply that the presence of pertactin-deficient strains may be influenced by the widespread use of the acellular vaccine in other regions, necessitating further research in places like Argentina that primarily utilize whole-cell vaccines.
Article Synopsis
- Pertussis, a respiratory disease, has seen a resurgence partly due to the switch from whole-cell pertussis vaccines to acellular vaccines, which offer limited protection and durability.
- A new vaccine candidate using outer membrane vesicles (OMVs) was developed, showing promise in protecting against strains of pertussis that are deficient in specific antigens, such as pertactin (PRN).
- The OMV vaccine effectively induces long-lasting immune responses, promoting a specific type of T cell that contributes to sustained protection, unlike the current acellular vaccines.
is a respiratory-disease pathogen producing symptomatology similar to that of pertussis but of underestimated incidence and with no specific vaccine existing. We recently designed a vaccine candidate from outer-membrane vesicles (OMVs) that proved to be safe and protective in a murine-infection model. Based on protection recently reported for the O antigen in aqueous solution, we assessed here whether the O-antigen-containing lipopolysaccharide (BppLPS-O) embedded in the membranes, as present in -derived OMVs (OMVs(Bpp-LPS-O)), was the component responsible for that previously observed protection by OMVs.
View Article and Find Full Text PDFMaternal safety through pertussis vaccination and subsequent maternal-fetal-antibody transfer are well documented, but information on infant protection from pertussis by such antibodies and by subsequent vaccinations is scarce. Since mice are used extensively for maternal-vaccination studies, we adopted that model to narrow those gaps in our understanding of maternal pertussis immunization. Accordingly, we vaccinated female mice with commercial acellular pertussis (aP) vaccine and measured offspring protection against challenge and specific-antibody levels with or without revaccination.
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