Publications by authors named "Francisco C Savka"
The aminotransferase gene family in the model plant consists of 44 genes, eight of which are suggested to be alanine aminotransferases. One of the putative alanine aminotransferases genes, At3g08860, was attributed the function of alanine:glyoxylate aminotransferase/β-alanine:pyruvate aminotransferase based on the analysis of gene expression networks and homology to other β-alanine aminotransferases in plants. It was earlier demonstrated that At3g08860 is specifically upregulated in response to osmotic stress, but not other stresses (β-alanine is an osmoprotectant in plants).
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- The bacterium Verrucomicrobium spinosum has gained attention after its genome was sequenced, revealing key insights into its diaminopimelate/lysine biosynthesis via the DapL pathway.
- Research confirmed the functionality of its dapL gene by demonstrating that the cloned enzyme can complement E. coli mutants deficient in diaminopimelate and lysine.
- The study highlights the potential of targeting the DapL pathway in V. spinosum for antibiotic development, as it does not harm humans and can serve as a model for understanding gene essentiality in pathogens.