Publications by authors named "Francisco C A da Silveira"
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.
Bruno Leal Ilídio F Afonso Carlos R Rodrigues Paula A Abreu Rafael Garrett Francisco C A da Silveira
Bioorg Med Chem
September 2008
Article Synopsis
- Antibacterial resistance is a major global health issue, particularly concerning Staphylococcus epidermidis, which primarily affects vulnerable patients in hospital settings.
- A study evaluated two series of compounds: 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives, finding that the former exhibited significantly greater antibacterial properties against drug-resistant S. epidermidis strains.
- The structure-activity relationship analysis indicated that the arrangement of functional groups within the compounds notably influenced their effectiveness, with specific configurations leading to enhanced antibacterial activity.