Publications by authors named "Francisco Alicandri"
Article Synopsis
- PRAME and 5hmC are important biomarkers in melanoma, showing an inverse relationship where benign nevi have high 5hmC and low PRAME, while melanomas reverse this pattern.
- Research using various imaging and database analyses indicates that lower levels of 5hmC are linked to higher PRAME levels in both premalignant and malignant melanoma cells.
- The study suggests that TET2 plays a crucial role in regulating PRAME expression through DNA hydroxymethylation, highlighting the importance of epigenetic changes in melanoma development.
Depression is a common non-motor symptom in Parkinson's disease (PD) that includes anhedonia and impacts quality of life but is not effectively treated with conventional antidepressants clinically. Vagus nerve stimulation improves treatment-resistant depression in the general population, but research about its antidepressant efficacy in PD is limited. Here, we administered peripheral non-invasive focused ultrasound to hemiparkinsonian ('PD') and non-parkinsonian (sham) rats to mimic vagus nerve stimulation and assessed its antidepressant-like efficacy.
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