Publications by authors named "Francisca I Teles"
Article Synopsis
- Glioblastoma (GBM) is the most common primary brain tumor, with hypoxic regions promoting tumor growth through the accumulation of adenosine, which influences cell proliferation and survival.
- * In experiments, adenosine significantly decreased viability in human astrocytes (HA) but had no effect on GBM cell lines, suggesting GBM cells adapt to high adenosine levels.
- * The use of an adenosine kinase inhibitor reduced proliferation in both HA and GBM cells, indicating that GBM cells have a mechanism to counteract the effects of adenosine, driving their adaptation and resistance.
