Publications by authors named "Francisca Dayse Martins de Sousa"
Some genetic variations in cytokine genes can alter their expression and influence the evolution of (Mtb) infection. This study aimed to investigate the association of polymorphisms in cytokine genes and variability in plasma levels of cytokines with the development of tuberculosis (TB) and latent tuberculosis infection (LTBI). Blood samples from 245 patients with TB, 80 with LTBI, and healthy controls (n = 100) were included.
View Article and Find Full Text PDFApoptosis of macrophages infected by via Fas-FasL is an important immune mechanism against infection. This study investigated the association of tuberculosis (TB) with the presence of the polymorphisms -670A/G and -124A/G, the levels of sFas and sFasL, and the gene expression of and cytokines. Samples of 200 individuals diagnosed with TB and 200 healthy controls were evaluated.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the relationship between specific gene polymorphisms (TNFA -308G/A and IL10 -819C/T) and gene expression levels in patients with pulmonary and extrapulmonary tuberculosis, compared to a control group.
- Findings showed no significant link between gene polymorphisms and pulmonary tuberculosis, but TNFA -308G/A polymorphisms were associated with extrapulmonary cases.
- Additionally, lower TNFA expression levels in patients with pulmonary tuberculosis were linked to a potential anti-inflammatory effect that may help the bacteria persist in the host.
Article Synopsis
- A study evaluated 89 TB patients (75 with pulmonary TB and 14 with extrapulmonary TB) and 45 controls, focusing on demographic factors and cytokine levels.
- Patients with TB were typically older, married, had lower education levels, and lower family incomes, with all extrapulmonary TB patients reporting inability to work due to their condition.
- Elevated levels of the cytokine IFN-γ were linked to pulmonary TB, while lower levels were found in extrapulmonary cases, indicating that IFN-γ could help differentiate between the two forms of TB and plays a crucial role in the disease's progression.