Synergistic effect of hydralazine associated with triazoles on spp. in planktonic cells.

To evaluate the antifungal activity of hydralazine hydrochloride alone and in synergy with azoles against spp. and the action mechanism. We used broth microdilution assays to determine the MIC, checkerboard assays to investigate synergism, and flow cytometry and molecular docking tests to ascertain action mechanism.

Activity of arginine-phenylalanine and arginine-tryptophan-based surfactants against .

This study aimed to evaluate the antibacterial effect of two new cationic surfactants based on phenylalanine-arginine (LPAM) and tryptophan-arginine (LTAM). Antibacterial activity, mechanism of action and interactions with enzymes were measured through microbiological, flow cytometry and molecular docking assays, respectively. These compounds showed antibacterial activity in the range of 4.

Synergistic activity of diclofenac sodium with oxacillin against planktonic cells and biofilm of methicillin-resistant strains.

To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm. Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry. The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant strains.

Evaluation of the antifungal activity of midazolam against fluconazole-resistant spp. isolates.

The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical spp. in planktonic and biofilm form. The antifungal activity was observed using the broth microdilution technique.

Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin.

The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.

Antifungal activity of β-lapachone against azole-resistant spp. and its aspects upon biofilm formation.

The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of spp. in both planktonic and biofilm form. The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay.

Synergistic anticandidal activity of etomidate and azoles against clinical fluconazole-resistant isolates.

The purpose of this study was to evaluate the effect of etomidate alone and in combination with azoles on resistant strains of spp. in both planktonic cells and biofilms. The antifungal activity of etomidate was assessed by the broth microdilution test; flow cytometric procedures to measure fungal viability, mitochondrial transmembrane potential, free radical generation and cell death; as well detection of DNA damage using the comet assay.