Publications by authors named "Francis X Pedlow"
Study Design: Retrospective case series.
Objective: To determine the effect of modern surgical and aggressive radiation techniques on outcome in patients with spinal chondrosarcoma.
Summary Of Background Data: Chondrosarcoma of the spine presents a difficult surgical challenge.
Background Context: Because of the low incidence, treatment recommendations for spinal osteosarcoma are guided by the results of small series and case reports. Many include patients who presented for treatment over the course of three to four decades.
Purpose: The goal of this investigation was to report the treatments, results, and overall survivorship of 26 patients treated for osteosarcoma of the spine at a single institution.
Article Synopsis
- This study evaluates a treatment strategy combining short preoperative radiation and targeted postoperative radiation for patients with bone tumors, particularly in the spine and pelvis, over a span of 24 years.
- Key findings reveal that 52% of patients had chordoma and the 5-year overall survival rate was 65%, with local control of tumors being achieved in 72% of cases; the study shows better outcomes for primary tumors compared to recurrent ones.
- The authors conclude that this approach is effective, helps reduce complications related to wound healing, and delivers higher radiation doses without significant damage to surrounding tissues, making it a promising option for patients facing surgical margins challenges.
Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas.
Int J Radiat Oncol Biol Phys
July 2009
Purpose: Radiotherapy (XRT) for spine sarcomas is constrained by spinal cord, nerve, and viscera tolerance. Negative surgical margins are uncommon; hence, doses of >or=66 Gy are recommended. A Phase II clinical trial evaluated high-dose photon/proton XRT for spine sarcomas.
View Article and Find Full Text PDFIntraoperative dural irradiation by customized 192iridium and 90yttrium brachytherapy plaques.
Int J Radiat Oncol Biol Phys
September 2003
Purpose: After vertebral or paravertebral tumor resection, tumor cells may remain on the dura. Because a tumoricidal dose is difficult to achieve using external beam radiotherapy without exceeding the spinal cord tolerance, we developed intraoperative applicators to deliver additional dose to the dura.
Methods And Materials: Eight patients with vertebral or paravertebral tumor underwent conformal external beam radiotherapy, tumor resection, and intraoperative radiotherapy to the dura involved by tumor.