Cerebrovascular disease in suspected non-Alzheimer's pathophysiology and cognitive decline over time.

Background: The underlying cause of cognitive decline in individuals who are positive for biomarkers of neurodegeneration (N) but negative for biomarkers of amyloid-beta (A), designated as Suspected non-Alzheimer's pathophysiology (SNAP), remains unclear. We evaluate whether cerebrovascular disease (CeVD) is more prevalent in those with SNAP compared to A-N- and A+N+ individuals and whether CeVD is associated with cognitive decline over time in SNAP patients.

Methods: A total of 216 individuals from a prospective memory clinic cohort (mean [SD] age, 72.