Publications by authors named "Francis Middleton"
This review summarises advances in research from Aotearoa, New Zealand (NZ) that have potential to reduce the inequitable distribution of acute rheumatic fever (ARF) and rheumatic heart disease (RHD). ARF incidence and RHD prevalence are unacceptably inequitable for Māori and Pacifica. Recent qualitative research has demonstrated mismatches between the lived experience of those with ARF/RHD and health service experience they encounter.
View Article and Find Full Text PDFArticle Synopsis
- Understanding the immune response in acute rheumatic fever (ARF) linked to group A strep (GAS) helps improve disease management and treatment.
- A notable increase in total IgG3 levels was found in ARF patients, significantly exceeding normal ranges, along with a strong inflammatory response indicated by interleukin-6 and C-reactive protein.
- The study highlights consistent antibody responses across the disease spectrum, with ARF showing greater intensity and suggests that testing for IgG3 could enhance clinical diagnosis of ARF.
Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD) are autoimmune sequelae of Group A Streptococcus infection with significant global disease burden. The pathogenesis of these diseases is poorly understood, and no immune modulating therapies are available to stop progression from ARF to RHD. Cytokines and chemokines are immune signaling molecules critical to the development of autoimmune diseases.
View Article and Find Full Text PDFBackground: The mRNA COVID vaccines are only licensed for intramuscular injection but it is unclear whether successful intramuscular administration is required for immunogenicity.
Methods: In this observational study, eligible adults receiving their first Comirnaty/BNT162b2 dose had their skin to deltoid muscle distance (SDMD) measured by ultrasound. The relationship between SDMD and height, weight, body mass index, and arm circumference was assessed.