Publications by authors named "Francis McGrath"
Article Synopsis
- Somatic mutations play a crucial role in cancer development, with many known driver mutations found in protein coding regions, but the impact of mutations in miRNAs and their binding sites is poorly understood.
- This study created cancer-specific miRNA regulatory networks for 30 cancer types, analyzing over 3.5 million mutations and revealing that mutations in miRNAs often occur alongside mutations in their target genes, influencing gene expression.
- The findings highlight 148 potential driver mutations that disrupt miRNA networks, suggesting that downregulated targets in 3' UTRs may act as tumor suppressors, and they introduce a web portal (mGI-map) to help researchers explore this data for future biomarker and drug development.
