Novel Isolates Alleviate Water Deficit Stress in Susceptible Tomato Genotypes.

Symbiotic fungi in the genus can induce abiotic stress tolerance in crops. The beneficial effects of on water deficit stress are poorly understood and may be isolate-specific. Our objective was to evaluate a collection of Nepalese isolates and their efficacy to improve tomato () growth under water deficit.

Complication Rates of Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-analysis.

Importance: Papillary thyroid microcarcinomas (PTMCs) have been associated with increased thyroid cancer incidence in recent decades. Total thyroidectomy (TT) has historically been the primary treatment, but current guidelines recommend hemithyroidectomy (HT) for select low-risk cancers; however, the risk-benefit ratio of the 2 operations is incompletely characterized.

Objective: To compare surgical complication rates between TT and HT for PTMC treatment.

-derived purple tomato fruit color is conferred by novel alleles of the and loci.

One hypothesis for the origin of endemic species of tomato on the Galápagos islands postulates a hybridization of and . accession LA1141 has purple fruit pigmentation, previously described in green-fruited wild tomatoes such as . or .

Metallic Nanoparticle Integrated Ternary Polymer Blend of PVA/Starch/Glycerol: A Promising Antimicrobial Food Packaging Material.

Advances in food processing and food packaging play a major role in keeping food safe, increasing the shelf life, and maintaining the food supply chain. Good packaging materials that enable the safe travel of food are often non-degradable and tend to persist in the environment, thereby posing a hazard. One alternative is to synthesize biodegradable polymers with an antimicrobial property while maintaining their mechanical and thermal properties.

Conceptualization of arid region radioecology strategies for agricultural ecosystems of the United Arab Emirates (UAE).

Since the last decade, ambitious nuclear power programmes have begun maturing in the Arab countries, most importantly in the United Arab Emirates (UAE). The region's environment and population, therefore, are prone to adverse, long-term impacts of radionuclide discharges. To calculate the associated exposure scenarios, to estimate doses and their consequences, and finally, to lay out a radiological emergency management plan, arid region radioecology is taking shape in the UAE as a major field of research.

Migration Drives the Replacement of Races in the Absence of Widely Deployed Resistance.

Changes in race and species composition causing bacterial spot of tomato have occurred throughout the world and are often associated with epidemics. Knowledge of bacterial population structure is key for resistance discovery and deployment. We surveyed spp.

Genetic variation of macronutrient tolerance in Drosophila melanogaster.

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D.

A Practical Approach for Monitoring the Use of Copy-Paste in Clinical Notes.

The use of copy-paste in authoring clinical notes has been widely embraced by busy providers, but inappropriate copy-paste has been lambasted by critics for introducing risks related to patient safety and regulatory compliance. At an integrated academic health system with over 4,100 providers writing notes, we developed a pragmatic approach to assess the use of copy-paste. From January 1-December 31, 2020, approximately 2.

Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy.

Due to their autosynchronous roles in shaping the anti-tumor immune response, complex immune regulatory networks acting both locally within the tumor microenvironment as well as in its draining lymph nodes play critical roles in the cancer immunotherapy response. We describe herein a thermosensitive co-polymer hydrogel system formed from biocompatible polymers gelatin and Pluronic F127 that are widely used in humans to enable the sustained release of a nitric oxide donor and antibody blocking immune checkpoint cytotoxic T-lymphocyte-associated protein-4 for efficient and durable anti-tumor immunotherapy. By virtue of its unique gel formation and degradation properties that sustain drug retention at the tumor tissue site for triggered release by the tumor microenvironment and formation of in situ micelles optimum in size for lymphatic uptake, this rationally designed thermosensitive hydrogel facilitates modulation of two orthogonal immune signaling networks relevant to the regulation of the anti-tumor immune response to improve local and abscopal effects of cancer immunotherapy.

Economic Inequality, the Digital Divide, and Remote Learning During COVID-19.

Wealth and education establish a cycle of intergenerational inequality. Wealthier households can provide more educational opportunities for their children, who then will have more chances to build wealth for themselves. The digital divide may have emerged as a key reinforcing mechanism of education through wealth and of future wealth through education during the pandemic.

Increased Shamal winds and dust activity over the Arabian Peninsula during the COVID-19 lockdown period in 2020.

While anthropogenic pollutants have decreased during the lockdown imposed as an effort to contain the spread of the Coronavirus disease 2019 (COVID-19), changes in particulate matter (PM) do not necessarily exhibit the same tendency. This is the case for the eastern Arabian Peninsula, where in March-June 2020, and with respect to the same period in 2016-2019, a 30 % increase in PM concentration is observed. A stronger than normal nocturnal low-level jet and subtropical jet over parts of Saudi Arabia, in response to anomalous convection over the tropical Indian Ocean, promoted enhanced and more frequent episodes of Shamal winds over the Arabian Peninsula.

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study.

Background: There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly elevated hsCRP beyond troponin in a large real-world cohort of unselected patients presenting with suspected acute coronary syndrome (ACS) is unknown. We evaluated whether a mildly elevated hsCRP (up to 15 mg/L) was associated with mortality risk, beyond troponin level, in patients with suspected ACS.

Steroidal alkaloid biosynthesis is coordinately regulated and differs among tomatoes in the red-fruited clade.

The tomato (Solanum spp.) clade of Solanaceae features a unique assortment of cholesterol-derived steroidal alkaloids. However, little quantitative data exists reporting the profile and concentration of these alkaloids across diverse fruit germplasm.

A double-blind randomised placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina without antianginal medications: design and rationale of the ORBITA-2 trial.

Percutaneous coronary intervention (PCI) is frequently performed for stable angina. However, the first blinded trial, ORBITA, did not show a placebo-controlled increment in exercise time in patients with single-vessel disease, at 6 weeks, on maximal antianginal therapy. ORBITA-2 will assess the placebo-controlled efficacy of PCI on angina frequency in patients with single- or multivessel disease, at 12 weeks, on no antianginal therapy.

Automatic Diagnosis Labeling of Cardiovascular MRI by Using Semisupervised Natural Language Processing of Text Reports.

Purpose: To assess whether the semisupervised natural language processing (NLP) of text from clinical radiology reports could provide useful automated diagnosis categorization for ground truth labeling to overcome manual labeling bottlenecks in the machine learning pipeline.

Materials And Methods: In this retrospective study, 1503 text cardiac MRI reports from 2016 to 2019 were manually annotated for five diagnoses by clinicians: normal, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy, myocardial infarction (MI), and myocarditis. A semisupervised method that uses bidirectional encoder representations from transformers (BERT) pretrained on 1.

ECG-based real-time arrhythmia monitoring using quantized deep neural networks: A feasibility study.

Continuous ambulatory cardiac monitoring plays a critical role in early detection of abnormality in at-risk patients, thereby increasing the chance of early intervention. In this study, we present an automated ECG classification approach for distinguishing between healthy heartbeats and pathological rhythms. The proposed lightweight solution uses quantized one-dimensional deep convolutional neural networks and is ideal for real-time continuous monitoring of cardiac rhythm, capable of providing one output prediction per second.

Search for Lepton-Flavor Violation in Z-Boson Decays with τ Leptons with the ATLAS Detector.

A search for lepton-flavor-violating Z→eτ and Z→μτ decays with pp collision data recorded by the ATLAS detector at the LHC is presented. This analysis uses 139  fb^{-1} of Run 2 pp collisions at sqrt[s]=13  TeV and is combined with the results of a similar ATLAS search in the final state in which the τ lepton decays hadronically, using the same data set as well as Run 1 data. The addition of leptonically decaying τ leptons significantly improves the sensitivity reach for Z→ℓτ decays.

Clinicodemographic Predictors of Tracheotomy Tube Size and Decannulation: A Multiinstitutional Retrospective Cohort Study on Tracheotomy.

Objective: We aimed to discern clinico-demographic predictors of large (≥8) tracheostomy tube size placement, and, secondarily, to assess the effect of large tracheostomy tube size and other parameters on odds of decannulation before hospital discharge.

Summary Of Background Data: Factors determining choice of tracheostomy tube size are not well-characterized in the current literature, despite evidence linking large tracheostomy tube size with posttracheotomy tracheal stenosis. The effect of tracheostomy tube size on timing of decannulation is also unknown, an important consideration given reported associations between endotracheal tube size and probability of failed extubation.

Feasibility of Screening for Chromosome 15 Imprinting Disorders in 16 579 Newborns by Using a Novel Genomic Workflow.

Importance: Newborn screening for Angelman syndrome (AS), Prader-Willi syndrome (PWS), and chromosome 15 duplication syndrome (Dup15q) may lead to benefit from early diagnosis and treatment.

Objective: To examine the feasibility of newborn screening for these chromosome 15 imprinting disorders at population scale.

Design, Setting, And Participants: In this diagnostic study, the validation data set for the first-tier SNRPN test, called methylation-specific quantitative melt analysis (MS-QMA), included 109 PWS, 48 AS, 9 Dup15q, and 1190 population control newborn blood spots (NBS) and peripheral tissue samples from participants recruited from January 2000 to December 2016.

Why Do I Get Side Effects? Personalized (N-of-1) Trials for Statin Intolerance and the Nocebo Effect.

The ability of statins to reduce the morbidity and mortality of cardiovascular disease has ensured that they are among the most prescribed drugs in modern medicine. Unfortunately, most patients who start taking statins will end up stopping them, most commonly due to side effects. Confusingly, however, in blinded placebo-controlled trials, side effects appear no more common in those taking statins than those taking placebo.

Optimizing atrio-ventricular delay in pacemakers using potentially implantable physiological biomarkers.

Background: Hemodynamically optimal atrioventricular (AV) delay can be derived by echocardiography or beat-by-beat blood pressure (BP) measurements, but analysis is labor intensive. Laser Doppler perfusion monitoring measures blood flow and can be incorporated into future implantable cardiac devices. We assess whether laser Doppler can be used instead of BP to optimize AV delay.

Physical Therapy for Muscle Tension Dysphonia with Cervicalgia.

Objectives: This study investigated the effectiveness of a specialized manual physical therapy (PT) program at improving voice among patients diagnosed with concomitant muscle tension dysphonia (MTD) and cervicalgia at a tertiary care voice center.

Materials And Methods: Cervicalgia was determined by palpation of the anterior neck. Both voice therapy (VT) and PT was recommended for all patients diagnosed with MTD and cervicalgia.

Ebullition enhances chemical mass transport across the tailings-water interface of oil sands pit lakes.

Base Mine Lake (BML) was the first commercial-scale demonstration oil sands pit lake established in northern Alberta, Canada. Recent studies indicate that ebullition enhances internal mass loading of dissolved constituents during settlement and dewatering of methanogenic fluid fine tailings (FFT) below the overlying water cap. Here, we describe results of integrated field measurements and numerical modelling to (i) determine potential for ebullition and enhanced mixing within BML, and (ii) assess impacts on chemical mass transport across the tailings-water interface.