Publications by authors named "Francis Celii"

Endoscopic retrieval of embedded, proximally migrated, or fractured plastic biliary stents may be technically challenging and sometimes unsuccessful. Percutaneous transhepatic techniques have previously been described to assist in such challenging cases. Here in, we describe a difficult case in which all commonly described endoscopic and percutaneous techniques failed to retrieve a proximally migrated, fractured, and looped plastic biliary stent.

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Advances in oncologic treatment have improved survival rates, allowing late effects of radiotherapy to become more prevalent. Our patient, an 82-year-old woman with a remote history of right thigh basal cell carcinoma treated with resection and radiation therapy 18 years prior, presented with severe right thigh pain and inability to bear weight as she had suffered a femur fracture after a fall from standing. Initial imaging was suspicious for pathologic fracture secondary to malignancy due to imaging findings and because radiation-induced fractures have rarely been reported beyond 44 months from treatment.

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Article Synopsis
  • TP53 mutations are the most common genetic changes in breast cancer, linked to more aggressive disease and lower survival rates.
  • Researchers developed specific mutant mouse models to study how these mutations behave in breast epithelial cells within a normal environment.
  • The findings indicate that while p53R245W mutations lead to aggressive tumors with metastases, p53R172H requires additional factors for tumor development, providing insights for future cancer therapies.
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