Immigration Politics and Policymaking in the USA (2017-2021): Examining the Effect of Geopolitics on Public Attitude Towards Immigration Policies.

Previous attitudinal studies on immigration in the USA largely focus on the predictors of anti-immigration sentiments compared to examining immigration policies. The dearth of scientific enquiry about the latter necessitated the present study. By analyzing individual-level data ( = 1018) obtained from the Public Religion Research Institute (PRRI), we assess the effect of geopolitics-red and blue states and other factors on public attitude towards six immigration policies in the USA (2017-2021).

Crime and punishment in Saudi Arabia: Lashing, imprisonment, and other unusual punishments.

Objective: In this paper, we examine the antecedents of the sanctions of lashing and imprisonment for juveniles in Saudi Arabia.

Participants And Setting: The current study examined 437 court cases and files across several court systems in Saudi Arabia to determine the extent to which justice-involved youth are punished. The data were drawn from hundreds of court files and records received from several court systems in Saudi Arabia spanning 2010 to 2015.

Exploration of factors influencing court outcomes in cases involving minors as victims in Ghana.

Background: The factors that influence positive court outcomes for cases of child sexual abuse (CSA) have been studied in other contexts but very few such studies exist for Sub-Saharan countries. Knowledge of how such cases fare in these court systems is, however, important for a global assessment of such outcomes.

Objective: The study explored the predictive effect of the victim, complainant; offender and offence characteristics, and length of the trial on case disposition and dropout.

Global Analysis and Optimal Control Model of COVID-19.

COVID-19 remains the concern of the globe as governments struggle to defeat the pandemic. Understanding the dynamics of the epidemic is as important as detecting and treatment of infected individuals. Mathematical models play a crucial role in exploring the dynamics of the outbreak by deducing strategies paramount for curtailing the disease.

Mathematical modelling of the epidemiology of COVID-19 infection in Ghana.

In this paper, Covid-19 patients with self-immunity is incorporated in the Susceptible-Exposed-Infected-Quarantined-Recovered model is applied to describe the epidemiology of Covid-19 infection in Ghana. Based on data on the epidemiology of the Covid-19 infection in Ghana, we observed that, on an average, three persons contract the Covid-19 infection from an infected person daily based using the basic reproductive number ( ) derived from the SEIQR model. In addition, the threshold condition for the long term stability of the Covid-19 infection in Ghana is derived from this model.

Immigrants, Crime, and the American Dream: Testing a Segmented Assimilation Theory of Crime.

The immigrant-crime relationship is often misunderstood and highly complex. To date, criminological research has largely ignored theory testing of this relationship. This paper examines the extant literature on intergenerational offending amongst immigrant youth and subsequently tests whether the segmented assimilation theory- a theory borrowed from the interdisciplinary social sciences- adequately explains immigrant offending.

Nurses' and midwives' perspectives on participation in national policy development, review and reforms in Ghana: a qualitative study.

Background: The World Health Organization has admonished member countries to strive towards achieving universal health coverage (UHC) through actionable health policies and strategies. Nurses and midwives have instrumental roles in achieving UHC via health policy development and implementation. However, there is a paucity of empirical data on nurses and midwives' participation in policy development in Ghana.

Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications.

Nanoparticle-based radiosensitization of cancerous cells is evolving as a favorable modality for enhancing radiotherapeutic ratio, and as an effective tool for increasing the outcome of concomitant chemoradiotherapy. Nevertheless, delivery of sufficient concentrations of nanoparticles (NPs) or nanoparticle-based radiosensitizers (NBRs) to the targeted tumor without or with limited systemic side effects on healthy tissues/organs remains a challenge that many investigators continue to explore. With current systemic intravenous delivery of a drug, even targeted nanoparticles with great prospect of reaching targeted distant tumor sites, only a portion of the administered NPs/drug dosage can reach the tumor, despite the enhanced permeability and retention (EPR) effect.

Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial.

Background: Treatment of ventilated pneumonia is often unsuccessful, even when patients are treated according to established guidelines. Therefore, we aimed to investigate the efficacy of the combination drug device Amikacin Inhale as an adjunctive therapy to intravenous standard-of-care antibiotics for pneumonia caused by Gram-negative pathogens in intubated and mechanically ventilated patients.

Methods: INHALE was a prospective, double-blind, randomised, placebo-controlled, phase 3 study comprising two trials (INHALE 1 and INHALE 2) done in 153 hospital intensive-care units in 25 countries.

Riociguat for idiopathic interstitial pneumonia-associated pulmonary hypertension (RISE-IIP): a randomised, placebo-controlled phase 2b study.

Background: Idiopathic interstitial pneumonias are often complicated by pulmonary hypertension, increasing morbidity and mortality. There are no approved treatments for pulmonary hypertension associated with idiopathic interstitial pneumonia (PH-IIP). We aimed to evaluate the efficacy and safety of riociguat in patients with PH-IIP.

Novel bioerodable eluting-spacers for radiotherapy applications with dose painting.

Objective: To investigate feasibility of using bioerodable/bioerodible spacers (BES) over biodegradable spacers (BDS) loaded with gold nanoparticles for radiotherapy applications with dose-painting, and to explore dosimetric impact on dose enhancement ratio of different radioisotopes.

Methods: Analytical models proposed were based on experimentally reported erosion rate constant ( = 5. 5E-7 kgms ) for bioerodible polymeric matrix.

Trust and Confidence in Media and Criminal Justice Institutions.

In every society, the main purpose of the criminal justice system is to maintain social order and ensure that citizens comply with the law. To do this effectively, the police and court systems need citizen cooperation and obedience, and willingness to assist with criminal investigations and report crimes to the police. The purpose of this study is to examine the association between confidence in the media and confidence in the criminal justice institutions in South Africa.

Misconduct Within the "Four Walls": Does Organizational Justice Matter in Explaining Prison Officers' Misconduct and Job Stress?

Primarily, this article examines the role of organizational justice in understanding prison officers' behavior. The authors surveyed 169 correctional officers across five correctional facilities in Ghana to explore the role of three organizational justice dimensions in prison misconduct and job stress. Results from the negative binomial and ordinal logistic analyses revealed the significant contributions of two dimensions of organizational justice in explaining misconduct and stress among officers.

Fear of Crime in the Sanctuary: Comparing American and Ghanaian University Students' Fearfulness.

While much is known about fear of crime in the West, little is known about how fearfulness of crime develops in non-Western societies, especially among university students. Representing the first attempt to empirically compare levels of fear of crime between Ghanaian and U.S.

Modeling gold nanoparticle-eluting spacer degradation during brachytherapy application with in situ dose painting.

Objective: To investigate the dosimetric impact of slow vs burst release of gold nanoparticles (GNPs) from biodegradable brachytherapy spacers loaded with GNPs, which has been proposed to increase therapeutic efficacy during brachytherapy application with in situ dose painting.

Methods: Mathematical models were developed based on experimental data to study the release of GNPs from a spacer designed with poly(lactic-co-glycolic acid) polymer. The models addressed diffusion controlled-release process and poly(lactic-co-glycolic acid) degradation kinetics that were used to determine GNP concentration profiles in tumour and the corresponding dose enhancement.

Smart Radiation Therapy Biomaterials.

Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment.

Fearfulness in the Community: Empirical Assessments of Influential Factors.

Fear of crime has been well studied; however, there has yet not been widespread consideration of the potential impact of both individual- and neighborhood-level factors on residents' level of fear of crime. From a logistic-regression analytical standpoint, the present study empirically explores the contribution of several factors in explaining residents' propensity for being fearful of crime. Precisely, the study tests the applicability and generalizability of three theoretical perspectives of fear of crime in the Ghanaian context and examines the effects of residents' attitudes toward the police on their levels of fear of crime.

Crime Reporting Behavior: Do Attitudes Toward the Police Matter?

Police researchers have long argued that favorable evaluations of the police eventually lead to citizens' willingness to cooperate with the police. However, this assumption has barely been studied empirically. The current study examines the association between attitudes toward the police and crime reporting behavior of victims.

Riociguat for patients with pulmonary hypertension caused by systolic left ventricular dysfunction: a phase IIb double-blind, randomized, placebo-controlled, dose-ranging hemodynamic study.

Background: Pulmonary hypertension caused by systolic left ventricular dysfunction is associated with significant morbidity and mortality; however, no treatment is approved for this indication. We hypothesized that riociguat, a novel soluble guanylate cyclase stimulator, would have beneficial hemodynamic effects in patients with pulmonary hypertension caused by systolic left ventricular dysfunction.

Methods And Results: Overall, 201 patients with heart failure resulting from pulmonary hypertension caused by systolic left ventricular dysfunction were randomized to double-blind treatment with oral placebo or riociguat (0.

The Combined Effect of Nursing Support and Adverse Event Mitigation on Adherence to Interferon Beta-1b Therapy in Early Multiple Sclerosis: The START Study.

There is limited clinical evidence on the impact of nurse support and adverse event (AE) mitigation techniques on adherence to interferon beta-1b (IFNβ-1b) therapy in multiple sclerosis (MS) in a real-world setting. The aim of the Success of Titration, analgesics, and BETA nurse support on Acceptance Rates in MS Treatment (START) trial was to assess the combined effect of titration, analgesics, and BETA (Betaseron Education, Training, Assistance) nurse support on adherence to IFNβ-1b therapy in patients with early-onset MS and to evaluate safety. Participants were instructed to titrate IFNβ-1b and use analgesics to minimize flu-like symptoms.

250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study.

Background: The aim of the Betaferon Efficacy Yielding Outcomes of a New Dose (BEYOND) trial was to compare the efficacy, safety, and tolerability of 250 microg or 500 microg interferon beta-1b with glatiramer acetate for treating relapsing-remitting multiple sclerosis.

Methods: Between November, 2003, and June, 2005, 2447 patients with relapsing-remitting multiple sclerosis were screened and 2244 patients were enrolled in this prospective, multicentre, randomised trial. Patients were randomly assigned 2:2:1 by block randomisation with regional stratification to receive one of two doses of interferon beta-1b (250 microg or 500 microg) subcutaneously every other day or 20 mg glatiramer acetate subcutaneously every day.

Tolerability and safety profile of 12- to 28-week treatment with interferon beta-1b 250 and 500 microg QOD in patients with relapsing-remitting multiple sclerosis: a multicenter, randomized, double-blind, parallel-group pilot study.

Background: It is not known whether the currently available treatment regimen of interferon beta-1b (IFNbeta-1b) 250 microg provides the maximum benefit possible in the treatment of relapsing-remitting multiple sclerosis (RRMS), or whether higher doses of IFNbeta-1b will prove to be more beneficial.

Objective: The objective of the present study was to evaluate the tolerability and safety profile of IFNbeta-1b 500 microg compared with the currently approved 250-microg dose.

Methods: A multicenter, randomized, double-blind, parallel-group pilot study was carried out to compare IFNbeta-1b 250 microg with IFNbeta-1b 500 microg, both self-administered SC QOD for >or=12 weeks in patients with RRMS.