Publications by authors named "Francis Anazodo"
In naïve mice, a fraction of CD8 T cells displaying high affinity for self-MHC peptide complexes develop into virtual memory T (TVM) cells. Due to self-reactivity, TVM cells are exposed to persistent antigenic stimulation, a condition known to induce T cell exhaustion. However, TVM cells do not exhibit characteristics similar to exhausted CD8 T (TEX) cells.
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- * Although chemotherapy is the standard treatment for cervical cancer in Sub-Saharan Africa, it has not delivered the expected survival rates, especially for patients diagnosed with advanced stages of the disease.
- * Immune checkpoint inhibitors have shown promise in improving survival for advanced cervical cancer and are included in treatment guidelines in high-income countries, but many African nations face challenges in accessing and utilizing these therapies effectively.
Graft tolerance is a pathophysiological condition heavily reliant on the dynamic interaction of the innate and adaptive immune systems. Genetic polymorphism determines immune responses to tissue/organ transplantation, and intricate humoral and cell-mediated mechanisms control these responses. In transplantation, the clinician's goal is to achieve a delicate equilibrium between the allogeneic immune response, undesired effects of the immunosuppressive drugs, and the existing morbidities that are potentially life-threatening.
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