Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana.

This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagya district, where the disease is endemic, were carried out. Thirty medicinal plants distributed in 19 families were reported to be used for schistosomiasis treatment in the survey.

root bark extract ameliorates paracetamol-induced liver toxicity in rats possibly via the attenuation of oxidative stress.

root bark is widely used in folk medicine to manage liver diseases, particularly, jaundice but its effect on paracetamol-induced liver toxicity (PILT) has not yet been validated. This study explored the ameliorative effect of ethanolic root bark extract of (ZAE) against PILT in rats. The flavonoid and phenolic content of ZAE was evaluated using Folin-Ciocalteau and aluminium trichloride colorimetric methods, respectively.

In Vitro and In Vivo Toxicological Evaluation of P: Beauv. (Avicenniaceae) Leaf Extract in a Rat Model.

is an important ethnomedicinal plant that has long been used to treat malaria and several other diseases. Despite the plant's antimalarial and other therapeutic properties, there is limited evidence-based data on its potential toxicity. Hence, the purpose of the current study was to assess the safety of leaf ethanolic extract (AAE).

Assessment of some quality parameters and chemometric-assisted FTIR spectral analysis of commercial powdered ginger products on the Ghanaian market.

Background: Roscoe (ginger) rhizome is a global spice with marked pharmacological activities and industrial applications. The demand for the powdered spice soared in the wake of the COVID-19 global pandemic. The present study sought to assess powdered ginger products on the Ghanaian market for some quality parameters and compare their chemical composition via chemometric analysis of their FT-IR data.

and antimalarial activities of P. Beauv. (Avicenniaceae) ethanolic leaf extract.

Background: The emergence of widespread drug-resistant strains of the malaria parasites militates against strives for more potent antimalarial drugs.

Aim: The present study evaluated the antimalarial activity of ethanolic crude extract and against -infected mice in anticipation of acquiring scientific evidence for it used by mangrove dwellers to treat malaria in Ghana.

Methodology: The pulverized dried leaves were extracted with 70% ethanol (v/v) and screened for phytochemicals using standard protocols.

Analgesic Effect of Involves Inhibition of Inflammatory Mediators and Modulation of K Channels, Opioidergic and Nitrergic Pathways.

The diversity offered by natural products has timelessly positioned them as a good source for novel therapeutics for the management of diverse medical conditions, including pain. This study evaluated hydro-ethanolic root bark extract of (ZAE) as well as β-amyrin and polpunonic acid isolated from the plant for analgesic property. The study also investigated the mechanism responsible for this action in the extract.

Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of J.B.Hall (Rubiaceae) in Murine Models.

Background: The present study aimed at validating the traditional use and toxicity profile of a methanolic extract of the aerial parts of in alleviating depression and anxiety disorders.

Method: The antidepressant effect of methanolic extract of (PAE 30, 100, and 300 mg/kg, .) was assessed in mice using the forced swim test (FST) and the tail suspension test (TST).

Seed Extract Attenuates the Ethanol-Induced Gastric Ulcer in Rats via the Inhibition of TNF- and INF- Levels and Modulation in the Expression of Ki67 Protein.

has been used to treat an upset stomach in African traditional medicine, but its efficacy and safety have not been scientifically studied. The present research is aimed at assessing the antiulcer property of the seed extract of the plant to validate its traditional claim. Rats were pretreated with three doses of aqueous extract of .

Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance.

The majority of indigenes in the rural areas of Ghana use herbal medicines for their primary health care. In this study, an ethnobotanical survey was undertaken to document medicinal plants used by traditional healers in the Ejisu-Juaben district in the Ashanti region of Ghana to treat infections and to further investigate the antibiofilm formation properties of selected plants in resisting pathogenic bacteria. Seventy medicinal plants used by traditional practitioners for the treatment of skin infections and wounds were documented from the ethnobotanical survey.

Ethnopharmacological evaluation of schistosomicidal and cercaricidal activities of some selected medicinal plants from Ghana.

Background: The adulticidal and cercaricidal activities of five Ghanaian medicinal plants, namely, , , , and against were evaluated in this study. Six weeks old ICR mice ( = 25) were percutaneously infected with . cercariae.