Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent.

Objective: Previous studies have suggested that delayed gastric emptying and abnormal postprandial release of hormones that influence satiation, particularly cholecystokinin (CCK), may play an important role in the pathophysiology of bulimia nervosa (BN). This study was designed to test these hypotheses as well as the efficacy of the prokinetic agent erythromycin in patients with BN.

Method: Thirty-two normal-weight women with BN and 24 control participants consumed a large liquid test meal.

The development of hunger and fullness during a laboratory meal in patients with binge eating disorder.

Objective: This study aimed to test the hypothesis that, compared to similarly obese participants without BED, individuals with BED have a disturbance in the development of fullness and reduction of hunger during the course of a standard meal of large size.

Method: Thirteen patients with BED and 14 obese control participants consumed 975 g of a milkshake. Participants received no information about how much they had eaten or how much of the meal remained to be consumed.