Publications by authors named "Francine D Kouemo Motse"
Deletions of Histidine-Rich Protein 2/3 Genes in Natural Plasmodium falciparum Populations from Cameroon and India: Role of Asymptomatic and Submicroscopic Infections.
Am J Trop Med Hyg
June 2024
The bulk of malaria rapid diagnostic tests (RDTs) target histidine-rich protein 2 of Plasmodium falciparum, the deadliest malaria species. The WHO considers pfhrp2/3 deletions as one of the main threats to successful malaria control and/or elimination; as such, parasites that lack part or all of the pfhrp2 gene are missed by pfHRP2-targeting RDTs. Such deletions have been reported in several African and Asian countries, but little is known in Cameroon and India.
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- The study focuses on drug resistance genes in Plasmodium vivax (Pv) and Plasmodium falciparum (Pf) co-infections misdiagnosed as Pf mono-infections in Cameroon, highlighting an increasing prevalence of non-falciparum malaria.
- A specific mutation in the pvdhps gene (A383G) was identified, and Pv strains showed close genetic similarity to reference strains from Southeast Asia and the Western Pacific.
- No resistance mutations were found in key Pf genes (Pfmdr1 and Pfk13), but mutations were noted in Pfcrt and Pfdhfr-Pfdhps genes, with no G6PD deficiency mutations detected in patients
Background: There are growing reports on the prevalence of non-falciparum species and submicroscopic infections in sub-Saharan African countries but little information is available from Cameroon.
Methods: A hospital-based cross-sectional study was carried out in four towns (Douala, Maroua, Mayo-Oulo, and Pette) from three malaria epidemiological strata (Forest, Sahelian, and Soudanian) of Cameroon. Malaria parasites were detected by Giemsa light microscopy and polymerase chain reaction (PCR) assay.
The performances of a commonly used Plasmodium falciparum-detecting rapid diagnostic test (RDT) were determined in symptomatic individuals living in Cameroon. Discrepancies between RDT and light microscopy (LM) results were further investigated, with a focus on non-falciparum malaria (NFM) which are still largely understudied in sub-Saharan Africa (sSA) countries. In the present study, a total of 355 individuals aged 1-65 years were enrolled in the study.
View Article and Find Full Text PDFObjectives: To determine the prevalence and risk factors associated with rifampicin (RIF)-resistant tuberculosis using GeneXpert technology.
Methods: A cross-sectional study was conducted from April 2018 to November 2019 among tuberculosis (TB)-infected Cameroonian patients in the Littoral Region using records from patients presenting with clinically suspected or documented TB. The patients were screened for TB using GeneXpert MDR/RIF ultra.