Absence of significant genetic alterations in the , , , and genes in Brazilian patients with Keratoconus.

Purpose: To identify inherited or acquired mutations in the and genes from the combined analysis of corneal and blood samples from patients with Keratoconus.

Methods: The casuistry was consisted of samples of peripheral blood and corneal epithelium from 35 unrelated patients with Keratoconus who were submitted to corneal crosslink treatment. Also, blood and corneal epithelium samples from 89 non-keratoconic patients were used to compose the control group.