Fully automated segmentation of the pons and midbrain using human T1 MR brain images.

Purpose: This paper describes a novel method to automatically segment the human brainstem into midbrain and pons, called labs: Landmark-based Automated Brainstem Segmentation. LABS processes high-resolution structural magnetic resonance images (MRIs) according to a revised landmark-based approach integrated with a thresholding method, without manual interaction.

Methods: This method was first tested on morphological T1-weighted MRIs of 30 healthy subjects.