Publications by authors named "Francesco Trapani"

Article Synopsis
  • Mammals with albinism have impaired visual discrimination and altered retinal cell makeup, affecting how retinal ganglion cells (RGCs) function.
  • The study used a mouse model of oculocutaneous albinism (Tyrc/c) to analyze RGC responses to light and assess differences in their receptive fields compared to normal mice.
  • Results showed similar receptive field sizes between albinism-affected and normal RGCs, but the albinism-affected RGCs exhibited more OFF responses and different polarity changes, indicating unusual adaptations during development due to the lack of eye pigments.
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Despite considerable progress in understanding the transition from algal forests to coralline barrens, knowledge of coralline barren ecosystems in terms of community composition and functioning is still sparse and important gaps remain to be filled. Using a barren/forest patch system, we tested the hypothesis that the presence of coralline barren enhances the abundance and diversity of benthic mega-invertebrates. We also analysed trophic functional diversity through isotopic analyses of δC and δN.

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Purpose: Cochlear implantation is a prevalent remedy for severe-to-profound hearing loss. Optimising outcomes and hearing preservation, and minimising insertion trauma, require precise electrode placement. Objective monitoring during the insertion process can provide valuable insights and enhance surgical precision.

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Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of inner retinal neurons is a promising avenue to restore vision in retinas having lost their photoreceptors. Expression of optogenetic proteins in surviving ganglion cells, the retinal output, allows them to take on the lost photoreceptive function.

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Article Synopsis
  • - Recent studies in the retina focus on classifying ganglion cells into different types using methods based on their responses to visual stimuli rather than just their receptive field properties.
  • - Two classification methods were compared: one that looks at the receptive field properties of ganglion cells and another that analyzes their responses to stimuli with varying temporal frequencies.
  • - The response-based method proved to be more effective in distinguishing different cell types because it incorporates nonlinear aspects of neuron functioning, enabling a more detailed classification of sensory neurons.
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We solve the time-dependent Fokker-Planck equation for a two-dimensional active Brownian particle exploring a circular region with an absorbing boundary. Using the passive Brownian particle as basis states and dealing with the activity as a perturbation, we provide a matrix representation of the Fokker-Planck operator and we express the propagator in terms of the perturbed eigenvalues and eigenfunctions. Alternatively, we show that the propagator can be expressed as a combination of the equilibrium eigenstates with weights depending only on time and on the initial conditions, and obeying exact iterative relations.

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We developed a multi-unit microscope for all-optical inter-layers circuits interrogation. The system performs two-photon (2P) functional imaging and 2P multiplexed holographic optogenetics at axially distinct planes. We demonstrated the capability of the system to map, in the mouse retina, the functional connectivity between rod bipolar cells (RBCs) and ganglion cells (GCs) by activating single or defined groups of RBCs while recording the evoked response in the GC layer with cell-type specificity and single-cell resolution.

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In many cases of inherited retinal degenerations, ganglion cells are spared despite photoreceptor cell death, making it possible to stimulate them to restore visual function. Several studies have shown that it is possible to express an optogenetic protein in ganglion cells and make them light sensitive, a promising strategy to restore vision. However the spatial resolution of optogenetically-reactivated retinas has rarely been measured, especially in the primate.

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Native generalist grazers can control the populations of non-indigenous invasive algae (NIIA). Here, it was found that the simultaneous consumption of two co-occurring NIIA, Caulerpa cylindracea and C. taxifolia var.

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Although protected areas can lead to recovery of overharvested species, it is much less clear whether the return of certain predator species or a diversity of predator species can lead to re-establishment of important top-down forces that regulate whole ecosystems. Here we report that the algal recovery in a Mediterranean Marine Protected Area did not derive from the increase in the traditional strong predators, but rather from the establishment of a previously unknown interaction between the thermophilic fish Thalassoma pavo and the seastar Marthasterias glacialis. The interaction resulted in elevated predation rates on sea urchins responsible for algal overgrazing.

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