Publications by authors named "Francesco Terzani"
The development of fast ligation chemistries for the site-specific modification of proteins has become a major focus in chemical biology. We describe steps for preparing an oxalyl thioester precursor in the form of an N-oxalyl perhydro-1,2,5-dithiazepine handle, i.e.
View Article and Find Full Text PDFCathepsin D (CD) is overexpressed in several types of cancer and constitutes an important biological target. Pepstatin A, a pentapeptide incorporating two non-proteinogenic statin residues, is among the most potent inhibitor of CD but lacks selectivity and suffers from poor bioavailability. Eight analogues of Pepstatin A, were synthesized, replacing residues in P3 or P1 position by non-canonical (S)- and (R)-α-Trifluoromethyl Alanine (TfmAla), (S)- and (R)-Trifluoromethionine (TFM) or non-natural d-Valine.
View Article and Find Full Text PDFArticle Synopsis
- A new peptide-based detection assay was developed to monitor anti-drug antibodies (ADAbs) in pediatric patients treated with Adalimumab for juvenile idiopathic arthritis (JIA) or chronic non-infectious uveitis (CNU).
- The study identified two synthetic peptides, HC3 and LC3, which successfully detected ADAbs in a test group, with HC3 finding ADAbs in 7 patients and LC3 in 11 patients.
- Results indicated that this peptide-based assay correlates with disease progression and remission, suggesting it could help clinicians make better-informed treatment decisions for patients.