Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine.

Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross the blood-brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect specific brain cells or areas. Functionalize nanoparticles with the most appropriate targeting elements, tailor their physical parameters, and consider the brain's complex anatomy are essential aspects for precise therapy and diagnosis.

Biocompatibility and Endothelial Permeability of Branched Polyglycidols Generated by Ring-Opening Polymerization of Glycidol with B(CF) under Dry and Wet Conditions.

Polyglycidol or polyglycerol (PG), a polyether widely used in biomedical applications, has not been extensively studied in its branched cyclic form (PG), despite extensive research on hyperbranched PG (HPG). This study explores the biomedical promise of PG, particularly its ability to cross the blood-brain barrier (BBB). We evaluate biocompatibility, endothelial permeability, and formation of branched linear PG (PG) as topological impurities in the presence of water.