Wiley Interdiscip Rev Nanomed Nanobiotechnol
September 2024
Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross the blood-brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect specific brain cells or areas. Functionalize nanoparticles with the most appropriate targeting elements, tailor their physical parameters, and consider the brain's complex anatomy are essential aspects for precise therapy and diagnosis.
View Article and Find Full Text PDFBiomacromolecules
June 2024
Polyglycidol or polyglycerol (PG), a polyether widely used in biomedical applications, has not been extensively studied in its branched cyclic form (PG), despite extensive research on hyperbranched PG (HPG). This study explores the biomedical promise of PG, particularly its ability to cross the blood-brain barrier (BBB). We evaluate biocompatibility, endothelial permeability, and formation of branched linear PG (PG) as topological impurities in the presence of water.
View Article and Find Full Text PDF