Publications by authors named "Francesco Rugolo"
Prostate cancer is the most frequently diagnosed cancer and the fifth leading cause of cancer death among men in 2020. The clinical decision making for prostate cancer patients is based on the stratification of the patients according to both clinical and pathological parameters such as Gleason score and prostate-specific antigen levels. However, these tools still do not adequately predict patient outcome.
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- Cancer cells, particularly in neuroblastoma, show a disruption in lipid metabolism due to the repression of the ELOVL4 gene by the oncogene MYCN.
- ELOVL4 is important for the differentiation of neurons and the accumulation of lipid droplets, and its repression by MYCN correlates with poor outcomes in cancer progression.
- Higher levels of ELOVL4 expression are linked to better prognosis in neuroblastoma patients, suggesting its potential as a biomarker for improved survival rates.
The human zinc finger (C2H2-type) protein ZNF750 is a transcription factor regulated by p63 that plays a critical role in epithelial tissues homoeostasis, as well as being involved in the pathogenesis of cancer. Indeed, missense mutations, truncation and genomic deletion have been found in oesophageal squamous cell carcinoma. In keeping, we showed that ZNF750 negatively regulates cell migration and invasion in breast cancer cells; in particular, ZNF750 binds and recruits KDM1A and HDAC1 on the LAMB3 and CTNNAL1 promoters.
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