Publications by authors named "Francesco Mattii"

Article Synopsis
  • The study demonstrates the use of Raman spectroscopy (RS) and surface-enhanced Raman spectroscopy (SERS) to measure intracellular cholesterol levels in human fibroblasts, critical for understanding cholesterol metabolism and diagnosing related disorders.
  • SERS proved to be more sensitive and accurate in detecting cholesterol levels in fibroblasts from patients with type C Niemann-Pick disease compared to RS and traditional fluorescent methods.
  • Researchers found that gold nanoparticles used in SERS were internalized by the cells and localized in lysosomes, enhancing the method's sensitivity and suggesting its potential for developing tools for screening and monitoring cholesterol-related diseases.
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Although visible light-based stereolithography (SLA) represents an affordable technology for the rapid prototyping of 3D scaffolds for in vitro support of cells, its potential could be limited by the lack of functional photocurable biomaterials that can be SLA-structured at micrometric resolution. Even if innovative photocomposites showing biomimetic, bioactive, or biosensing properties have been engineered by loading inorganic particles into photopolymer matrices, main examples rely on UV-assisted extrusion-based low-resolution processes. Here, SLA-printable composites were obtained by mixing a polyethylene glycol diacrylate (PEGDA) hydrogel with multibranched gold nanoparticles (NPs).

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Article Synopsis
  • Scientists created a special nanoplatform made of cellulose that helps treat a type of breast cancer called triple negative breast cancer (TNBC).
  • This platform uses sugar to target the cancer cells and deliver tiny particles called gold nanoparticles (AuNPs) right where they are needed.
  • When X-rays are used with this new method, it can improve how well the treatment works, allowing doctors to use less radiation for the same effect.
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