Publications by authors named "Francesco Maiellaro"
Article Synopsis
- This study investigates how right ventricular (RV) dysfunction affects the outcomes of patients with low-flow, low-gradient aortic stenosis (LFLG-AS) who are undergoing transcatheter aortic valve replacement (TAVR).
- Utilizing data from two Italian centers, it was found that RV dysfunction is linked to a significantly increased risk of all-cause death and major cardiovascular events after one year.
- The findings suggest that assessing RV dysfunction before TAVR can enhance the ability to predict patient prognosis.
Article Synopsis
- - The study aims to compare immediate versus staged percutaneous coronary intervention (PCI) strategies for patients with aneurysmatic right coronary artery (ARCA) during acute coronary syndrome (ACS), analyzing outcomes from 85 patients.
- - Results show that both PCI strategies had similar rates of procedural success and long-term outcomes, but the staged approach led to a higher incidence of bleeding and longer hospital stays.
- - The findings suggest that while both methods are viable, immediate PCI might be preferable due to lower complications and shorter hospital duration.
Article Synopsis
- * A study reporting five cases of ApHCM showed signs of intramyocardial calcification through echocardiograms and MRI findings, which suggested endomyocardial fibrosis (EMF) – a condition involving scarring of the heart tissue that can lead to further complications.
- * The analysis of patient histories indicated common inflammatory triggers, suggesting that these factors could contribute to small vessel disease and ischemic microvascular stress in conjunction with heart muscle thickening, ultimately resulting in fibrosis and calcification.
Article Synopsis
- A multicenter study analyzed the effectiveness and safety of intravenous antiplatelet therapies, cangrelor and tirofiban, in STEMI patients undergoing PPCI at seven Italian centers.
- The primary outcome measured was the incidence of TIMI flow < 3 after the procedure and the risk of bleeding (BARC 2-5) in patients receiving either treatment.
- Results showed that cangrelor led to better myocardial blood flow post-PPCI compared to tirofiban, without a higher risk of significant bleeding complications.
Primary percutaneous angioplasty (pPCI), represents the reperfusion strategy of choice for patients with STEMI according to current international guidelines of the European Society of Cardiology. Coronary no-reflow is characterized by angiographic evidence of slow or no anterograde epicardial flow, resulting in inadequate myocardial perfusion in the absence of evidence of mechanical vessel obstruction. No reflow (NR) is related to a functional and structural alteration of the coronary microcirculation and we can list four main pathophysiological mechanisms: distal atherothrombotic embolization, ischemic damage, reperfusion injury, and individual susceptibility to microvascular damage.
View Article and Find Full Text PDFChronic myeloid leukemia is a rare myeloproliferative disease, characterized by a chromosomal translocation detected in 95% of cases, defined as "Philadelphia chromosome", encoding for the BCR-ABL fusion protein with continuous activation of the tyrosine kinase domain. Over the last 20 years, treatment has been revolutionized by the use of BCR-ABL tyrosine kinase inhibitors (TKI). Imatinib is the first TKI approved with a good cardiovascular safety profile, while some second-generation (nilotinib and dasatinib) and third-generation (ponatinib) drugs, developed to overcame drug resistance, can be associated with cardiovascular adverse events.
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