and the Human Gastrointestinal Microbiota: A Multifaceted Relationship.

is a type of Gram-negative bacteria belonging to the Proteobacteria phylum which is known to cause gastrointestinal disorders such as gastritis and gastric ulcers. Its treatment is based on current eradication regimens, which are composed of combinations of antibiotics such as clarithromycin, metronidazole, levofloxacin and amoxicillin, often combined with a proton pump inhibitor (PPI). With the development of sequencing technologies, it has been demonstrated that not only does the colonization of the gastric and gut environment by cause microbial changes, but also the treatment regimens used for its eradication have a significant altering effect on both the gastric and gut microbiota.

The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy.

Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and the integrity of our intestinal barrier may play roles in the development of FA. Environmental factors, including industrialization and consumption of highly processed food, can contribute to altering the gut microbiota and the intestinal barrier, increasing the susceptibility to allergic sensitization.

Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota.

Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and cardiometabolic disorders. SCFAs are metabolites of specific bacterial taxa of the human gut microbiota, and their production is influenced by specific foods or food supplements, mainly prebiotics, by the direct fostering of these taxa. This Review provides an overview of SCFAs' roles and functions, and of SCFA-producing bacteria, from their microbiological characteristics and taxonomy to the biochemical process that lead to the release of SCFAs.

Histamine-producing bacteria and their role in gastrointestinal disorders.

Introduction: Gut microbiota produces thousands of metabolites, which have a huge impact on the host health. Specific microbial strains are able to synthesize histamine, a molecule with a crucial role in many physiologic and pathologic mechanisms of the host. This function is mediated by the histidine decarboxylase enzyme (HDC) that converts the amino acid histidine to histamine.

CAR-T-Derived Extracellular Vesicles: A Promising Development of CAR-T Anti-Tumor Therapy.

Extracellular vesicles (EVs) are a heterogenous population of plasma membrane-surrounded particles that are released in the extracellular milieu by almost all types of living cells. EVs are key players in intercellular crosstalk, both locally and systemically, given that they deliver their cargoes (consisting of proteins, lipids, mRNAs, miRNAs, and DNA fragments) to target cells, crossing biological barriers. Those mechanisms further trigger a wide range of biological responses.

Ortho-Perio Risk Assessment and timing flowchart for lingual orthodontics in an interdisciplinary adult ortho-perio patient: A case report of "Perio-Guided" Orthodontic treatment.

Introduction: The treatment of ortho-perio patients is a challenge for the interdisciplinary team. Not only are adult patients with overt perio pathology involved, but any ortho patient, even young ones, can be a perio patient and vice versa. Diagnosis and risk assessment of every ortho-perio patient is essential to establish a correct treatment plan, schedule and prognosis.

One-year impact of COVID-19 pandemic on Italian dental professionals: a cross-sectional survey.

Background: COVID-19 pandemic has disrupted the daily work of the dental professionals, assuming unprecedented economic, managerial, and psychological implications. The aim of this cross-sectional survey was to analyze the extent of the impact linked to the imposed working conditions on the Italian dental team.

Methods: The survey was administered with a web-based form (Google Forms; Google LLC, Mountain View, CA, USA) to Italian dentists and hygienists.

Lingual orthodontics in an adult patient with upper premolar extraction: Case report.

Objective: To show with this case report that lingual orthodontics can be a solution in complex adult situation and with interdisciplinary approach.

Materials And Methods: The patient presented a dental and skeletal high angle class II division 1 with a previous extraction of one mandibular incisor. The strategy of treatment was upper first premolar-extraction to obtain a correction of the incisal-class II relationship with a normal lip function, a class II molar relationship on the right side and a class I on the left side.