Publications by authors named "Francesco Isotti"
Article Synopsis
- Chronic mild stress (CMS) in rats is a widely used method to study depressive-like behaviors, revealing significant variability in how different protocols affect vulnerability to depression.
- Altered dopamine (DA) signaling in the corticolimbic system likely contributes to these behaviors, with specific changes in synaptic plasticity observed in the medial prefrontal cortex (mPFC) of vulnerable rats.
- Ketamine treatment appears to restore synaptic balance and counteracts chronic stress effects, highlighting its potential as an antidepressant and offering insights into the neurophysiological mechanisms of stress vulnerability.
The effect of stress on animal behavior and brain activity has been attracting growing attention in the last decades. Stress dramatically affects several aspects of animal behavior, including motivation and cognitive functioning, and has been used to model human pathologies such as post-traumatic stress disorder. A key question is whether stress alters the plastic potential of synaptic circuits.
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