Publications by authors named "Francesco Giorgelli"
Bioorg Chem
November 2019
Article Synopsis
- Diabetes is a complex disorder that requires treatments with multiple effective agents for better management.
- The study describes the creation of polyhydroxylated pyrrolidines that can inhibit two important enzymes, alpha-glucosidase and aldose reductase, which are linked to increased blood sugar levels and tissue damage in diabetes.
- One specific compound, 17b, not only reduced cell death but also helped restore normal oxidative stress levels in lab tests, indicating its potential effectiveness in treating diabetic retinopathy.
