Publications by authors named "Francesco Ghellere"
Article Synopsis
- Knee replacement surgery often leads to pain from prosthetic devices, prompting the exploration of bisphosphonates like clodronate (CLO) for treatment due to their analgesic and anti-inflammatory benefits.
- In a pilot study with 18 patients averaging 73 years old, participants received CLO alongside rehabilitation to assess changes in pain and functionality over 6 months, using pain and activity scores as metrics.
- Results showed significant reductions in pain (VAS score decrease) and improvements in functionality (higher TLS score), suggesting that CLO combined with rehab exercises effectively alleviates pain and enhances the function of knee prostheses, with a high initial dose proving more beneficial than weekly doses.
Objective: The duration of treatment with glucocorticoids (GC) in polymyalgia rheumatica (PMR) is often longterm. Amino bisphosphonates (N-BP) are used in PMR for the prevention of GC-induced osteoporosis, but they coulsd also have immunomodulatory properties. Whether they can be effective as an adjuvant treatment in PMR is unknown.
View Article and Find Full Text PDFAvailable studies reported contradictory results about serum levels Dickkopf-1 (DKK1), an inhibitor of Wnt signaling in patients with ankylosing spondylitis (AS). In previous studies, we observed in other conditions that parathyroid hormone (PTH) serum levels were an important determinant of DKK1 serum levels. The aim of the present study was to investigate it in patients with AS.
View Article and Find Full Text PDFPatients with ankylosing spondylitis (AS) have an increased risk of bone loss and vertebral fractures. In this study, we explored the hypothesis that the excess bone loss and vertebral fractures might be related with the activity of the Wingless signaling pathway, and in particular with the serum levels of its circulating inhibitors, Sclerostin and Dickkopf-1 (DKK1). We recruited 71 patients diagnosed with AS.
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