Association between causative mutations and response to PCSK9 inhibitor therapy in subjects with familial hypercholesterolemia: A single center real-world study.

Background And Aims: Familial hypercholesterolemia (FH) is an autosomal dominant disease that leads to cardiovascular (CV) disease. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9-I) demonstrated efficacy in low-density lipoprotein cholesterol (LDL-C) reduction and in prevention of CV events. The aim of our study is to evaluate the relationship between LDL receptor (LDLR) mutations and response to PCSK9-I therapy.

Association of apolipoprotein levels with peripheral arterial disease: a meta-analysis of literature studies.

Aims: Lower limb peripheral artery disease (PAD) is a leading cause of atherosclerotic cardiovascular disease (ASCVD). Discordant data are available on the association between apolipoprotein and PAD. We performed a meta-analyses on the association between apolipoprotein (apo)B, apoA-I, and apoB/apoA-I ratio with PAD.

Association of systemic lupus erythematosus with peripheral arterial disease: a meta-analysis of literature studies.

Objective: SLE patients have an increased cardiovascular morbidity and mortality. Contrasting data are available about the association between peripheral arterial disease (PAD) and SLE. We aimed to perform a meta-analysis of studies evaluating the association between SLE and PAD.

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background Bempedoic acid (BA) is a novel lipid-lowering drug. We performed a systematic review and meta-analysis on efficacy and safety of BA compared with standard treatment in patients with hypercholesterolemia. Methods and Results Studies were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases.

Speckle tracking echocardiography in patients with systemic lupus erythematosus: A meta-analysis.

Background: Systemic lupus erythematosus (SLE), is characterized by a systemic involvement including myocardial dysfunction. Being standard echocardiography not able at fully detecting subclinical alterations, speckle tracking echocardiography (STE) has recently emerged as a quantitative ultrasound technique to accurately estimate myocardial function.

Methods: We conducted a systematic review with meta-analysis of studies reporting STE parameters in patients with SLE.

Association of Vitamin D deficiency with peripheral arterial disease: a meta-analysis of literature studies.

Context: Vitamin D deficiency patients have an increased cardiovascular (CV) morbidity and mortality. Contrasting data are available about the association between peripheral arterial disease (PAD) and Vitamin D status.

Objective: To perform a meta-analysis of studies evaluating the association between Vitamin D status and PAD.

The use of odds ratio in the large population-based studies: Warning to readers.

When researchers conduct large prospective studies, they provide results generating statistical analysis; therefore readers need considerable familiarity with descriptive and inferential statistics. If quantitative judgments are based on interpreting odds ratios as though they were relative risks, they are unlikely to be seriously in error. Because of the calculating method, the OR is often less precise than the RR in estimating the strength of an association, and this should definitely be kept in mind by anyone who reads and interprets the results of a large population based-study.