Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?

Objective: To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy.

Methods: Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system.

Results: PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis.