Publications by authors named "Francesco De Sanctis"
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Synopsis of recent research by authors named "Francesco De Sanctis"
- Francesco De Sanctis's recent research primarily focuses on understanding and overcoming immunosuppressive mechanisms and chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC) to enhance the effectiveness of existing cancer therapies.
- His studies reveal how specific proteins, like claudin 18 and SEMA3A, influence immune cell infiltration and tumor aggression, indicating potential therapeutic targets to manipulate the tumor microenvironment and improve patient responses to immunotherapy.
- De Sanctis also investigates the metabolic pathways involved in myeloid-derived suppressor cells (MDSCs), aiming to develop innovative strategies to inhibit these cells and boost anti-tumor immunity, thereby paving the way for better integration of immune checkpoint inhibitors in cancer treatment.
