Publications by authors named "Francesco De Laurentiis"

Background: Differential diagnosis between uterine leiomyomas and sarcomas is challenging. Magnetic resonance imaging (MRI) represents the second-line diagnostic method after ultrasound for the assessment of uterine masses.

Objectives: To assess the accuracy of MRI in the differential diagnosis between uterine leiomyomas and sarcomas.

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Article Synopsis
  • Endometrial cancer arising in adenomyosis (EC-AIA) is a rare and challenging uterine disease with malignant transformations often occurring in menopausal women.
  • The study reviewed existing literature from 2002 to 2022, analyzing 37 cases found in case reports and series, highlighting that EC-AIA shares symptoms with regular endometrial cancer but is more difficult to diagnose preoperatively.
  • Key findings indicate EC-AIA has a higher prevalence of non-endometrioid histotypes and advanced cancer stages, leading to a worse prognosis, emphasizing the need for more extensive future research to better understand this condition.
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In recent years, heavy metals (HMs) levels in soil and vegetation have increased considerably due to traffic pollution. These pollutants can be taken up from the soil through the root system. The ability of plants to accumulate HMs into their tissues can therefore be used to monitor soil pollution.

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The present study aims to highlight the therapeutic potential of (), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed.

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Heavy metals can cause several genotoxic effects on cells, including oxidative stress, DNA sequence breakage and protein modification. Among the body organs, skin is certainly the most exposed to heavy metal stress and thus the most damaged by the toxic effects that these chemicals cause. Moreover, heavy metals, in particular nickel, can induce the over-expression of collagenases (enzymes responsible for collagen degradation), leading to weakening of the skin extracellular matrix.

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